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Ultimate Antibody Cures Every Type Of Cancer In Clinical Tests (VIDEO)
EXCERPT:
Cancer researchers made a groundbreaking discovery by developing a sort-of “Ultimate antibody” — a single treatment that has been shown to kill every type of cancer it was tested on.
The latest developments are based on research that began a decade ago at Stanford School of Medicine, where researchers discovered a link between cancer cells and high levels of a protein called CD47 while studying leukemia. Irving Weissman, the biologist behind the breakthrough, continued to study CD47 and found at a CD47-blocking antibody that could cure some cases of leukemia by stimulating the immune system to recognize cancer cells as invaders.
Now, Weissman has established a link between CD47 and most of primary caners that affect humans, finding that cancer cells always had higher levels of CD47 than healthy cells. The inordinate amounts of CD47 produced by the cancer cells effectively trick the immune system into not destroying the cancer cells.
“What we’ve shown is that CD47 isn’t just important on leukemias and lymphomas,” says Weissman, according to Science magazine. “It’s on every single human primary tumor that we tested.”
Weissman and his team used that observation to develop an antibody that blocks cancer cells’ CD47, causing the body’s immune system to attack the cancerous cells.
In tests on laboratory mice infected with a litany human cancers — breast, ovarian, colon, bladder, brain, liver prostate — the antibody was shown to force the mice’s immune systems to kill the tumorous cells.
“We showed that even after the tumor has taken hold, the antibody can either cure the tumor or slow its growth and prevent metastasis,” said Weissman.
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FROM THE VIDEO...
The next step is for clinical tests in humans, which should be underway thanks to a $20 million grant by the California Institute for Regenerative Medicine to move the findings to human safety tests, which was granted in 2012, after the study took place.
“We have enough data already that I can say I’m confident that this will move to phase I human trials,” said Weissman.
MORE HERE:
Scientists Have Silver Bullet To Kill Multiple Cancers, Human Trials Starting
EXCERPT:
Researchers have previously noticed that a specific surface marker, called CD47, was expressed at high levels on cancer cells and cells in the blood. They found that this CD47 molecule signals the immune system to ‘not eat me,’ and protects cells from being killed off. Cancers use this flag to evade the immune system and hide while it grows and eventually spreads through the body, ignored by the immune system.
Recently the lab of Irving Weissman at the Stanford University School of Medicine in Palo Alto, California has treated mice with leukemias and lymphomas with an antibody that blocks and effectively hides this CD47 marker and calls on the immune system to attack and kill the cancerous cells.
Now in the most recent publication, Weissman and his research group has gone a step further and tested multiple types of human cancer cells including breast, ovary, colon, bladder, brain, liver, and prostate tumors in petri dishes and in mice to determine the effectiveness of this ‘Anti-CD47’ antibody treatment.
In vitro, in petri dishes, researchers found that when they blocked this ‘do not eat me’ signal, macrophages, a type of immune cell that eats harmful cells and bacteria, killed and ate the cancer cells. And without the drug, the macrophages ignored the cancer cells completely.
In mice, researchers transferred multiple types of human cancer cells, which would normally grow large, metastasize and eventually kill the mouse. Yet, the mice treated with the drug all had shrinkage of tumors, no evidence of cancer spread to lymph nodes and remained cancer free for four months after researchers stopped the treatment (when the experiment was completed).
From the Science editorial “In mice given human bladder cancer tumors, for example, 10 of 10 untreated mice had cancer that spread to their lymph nodes. Only one of 10 mice treated with anti-CD47 had a lymph node with signs of cancer.”
The editorial continues: Cancer researcher Tyler Jacks of the Massachusetts Institute of Technology in Cambridge says that although the new study is promising, more research is needed to see whether the results hold true in humans. “The microenvironment of a real tumor is quite a bit more complicated than the microenvironment of a transplanted tumor,” he notes, “and it’s possible that a real tumor has additional immune suppressing effects.”
Weissman’s research laboratory has received a $20 million grant from California Institute for Regenerative Medicine to move from mouse trials to safety tests in humans (Phase I trials).
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My uncle just passed from stomach and bone cancer. Though too late for him, this is excellent news!
I must admit, this line just about slowed me down....
“So far, researchers have used the antibody in mice with human breast”, but I kept on reading and now I don’t have an image in my head of mice with female boobs in a lab somewhere.
Other than that, this is really great news.
Incredible.
AMA & AHA will buy up rights and it’ll sent to Warehouse 13.
Bump.
This is irresponsible reporting.
Killing cancer cells in mice is nothing new. Virtually every cancer drug or compound out there did well with testing in mice.
BUT, only a small fraction are able to get approved and pass the initial human trial tests of toxicity before reaching effective dose levels.
Many fail because the liver won’t process them properly.
This product is years away from completing just the Phase1 human trial, if it gets approved for human testing.
There is a drug currently in human trials at the Harvard Cancer complex (Dana Farber Hospital) that has a different MOA from the product hyped in the news releases.
It is Kevetrin, and it is very promising. Several other prominent cancer research hospitals have started or are soon to start additional trials using K with compounds already approved.
I’ll be the cynic and say this drug will never make it to human trials.
Way too much money is being made in the treatment of cancer to allow one drug to take down an entire industry. Ain’t gonna happen, which is a shame.
And under Obamacare, if youre above the age of 65 with cancer, they’ll refuse to give you this cure. Giving you a pain pill and a pamphlet on assisted suicide instead.
The population control crowd isn’t going to like this.
Our current govt will approve this treatment AFTER all the baby boomers are long dead. They have to find a way to sustain Social Security you know. Can’t be lettin those SS/Medicare hangers on live too long you see.
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