It’s always unsafe to an extent as there are never any guarantees but age 35 is used as the standard for AMA (Advanced Maternal Age) because at that point the risks from getting an amnio are the same as the risk of having a child with Down Syndrome. From what I’ve read, the real risks of pregnancy don’t get really bad until about age 42 and then it skyrockets.
Perfect ‘birthing age’(for both parents) is 17 - 23, IMO.
I’m in my mid 30s myself, and have some small children. When I was 20, I was VERY MUCH more able to keep up with them. lol It doesn’t seem to phase my wife any. She could probably have 6 more, keep her 115lb body weight, and run after them just as she did when she was 19. She’s like a machine. lol
| Age (years) | Frequency of Fetuses with Down Syndrome to Normal Fetuses at 16 weeks of pregnancy |
Frequency of Live Births of Babies with Down Syndrome to Normal Births |
|---|---|---|
| 15 - 19 | ---- | 1 / 1250 |
| 20 - 24 | ---- | 1 / 1400 |
| 25 - 29 | ---- | 1 / 1100 |
| 30 - 31 | ---- | 1 / 900 |
| 32 | ---- | 1 / 750 |
| 33 | 1 / 420 | 1 / 625 |
| 34 | 1 / 325 | 1 / 500 |
| 35 | 1 / 250 | 1 / 350 |
| 36 | 1 / 200 | 1 / 275 |
| 37 | 1 / 150 | 1 / 225 |
| 38 | 1 / 120 | 1 / 175 |
| 39 | 1 / 100 | 1 / 140 |
| 40 | 1 / 75 | 1 / 100 |
| 41 | 1 / 60 | 1 / 85 |
| 42 | 1 / 45 | 1 / 65 |
| 43 | 1 / 35 | 1 / 50 |
| 44 | 1 / 30 | 1 / 40 |
| 45 and older | 1 / 20 | 1 / 25 |