[r9etb]

The only better model systems than rats and mice are non-human primates, and that is because the close genetic similarity we share with rats and mice is even greater between us and other primates.

In Type I diabetes studies, at least, mouse results are notorious for not carrying over well into humans.

Given that Type I diabetes and the inflammation response reported here are both autoimmune responses, I have a strong suspicion that the results reported here will similarly not carry over well to humans.

[allmendream]

For this type of auto-immunity you may well be correct as to the limited applicability of data from mice.

But if mouse data was of no use, then private biological research corporations wouldn't waste billions of dollars a year screening compounds for safety and efficacy in mice.

Usually if it works in rodents, dogs, and non-human primates; it will work in humans.

Primates are, of course, the best model; as their biological molecules are above 95% the same as humans, and the < 5% differences are usually in non functional areas.