Newly manufactured brass is now widely available, loading is not a problem, although converting .223/5.56 brass can be a pleasant task. My rifle has never seen a factory round.
Cool. But so is a 556/223 with the proper bullet, or a 762x39 or a 30/0 or a myriad of other calibers. Plus, the 556 carries that capability to ariund 400 yards easily ( 70 grn TSX or Horn GMX with aplomb....
But hey, real hunters use rounds that are more than adequate. Or they ought to. When a misplaced round wont do the job, a full up rifle round usually does.
That said, I routinely use 223/556 carbine for short range Missouri deer, or even my carry mini glock 40.... It all boils down to engagement parameters and performance envelope.
I also have used my 416 Rigby for the same critters ( can you actually have too much gun? Nope).