If the opportunity presents itself, try to take the painlessness out of opposing the Tea Party and conservatives. Let the chamber of commerce, for example, know that there will be payback.
And be clear, that this payback is not for opposing conservative candidates; but for supporting establishment Republicans *against* the United States of America.
That is, put it in terms of patriotism. Either they are supporters of “internationalism”, *or* they are supporters of America. They cannot be both. And if they are internationalists, they might as well start packing, to leave the US and take up residence with their internationalist friends, if they will have them.
Force a splintering in the CoC, they’re local at base. Not all chambers will be on board. I’d say a majority in red states outside larger metros are vulnerable to local citizen pressure.