Invest in items that will have greater wealth once things go south... or in the ability to acquire those items at that time.
My 401 got hammered and has still not recovered fully. I also had some major medical bills for a child that cost me. I changed jobs recently and cashed in my 401 and paid off all debt. Sold the house and and am currently leasing so I am not tied down.
Over the last couple years I have bought ammo and some dry goods and basically sitting on what is left of the cash and buying some hard assets.