“””healthcare professionals, who seem hesitant to prescribe the most effective outpatient treatment for COVID — nirmatrelvir/ritonavir (Paxlovid) —””””
Is Paxlovid really that effective? It seems I have read previous threads stating that Paxlovid is not effective.
Paxlovid seems to cause rebound infections. It does not seem effective at all; just another reformulated drug so big pharma can slap an expensive price tag on it and make fat money
Is there anything you actually agree with in this author’s writing?
He sounds like a first-class loon, to me. So, for me the answer is No, I don’t expect Paxlovid to be the panacea he claims it is. Paxlovid will suspend the advance of a virus while you’re on it, but you are still going to need an immune system to get rid of it. At least, that is my understanding.
Something very strange, in my opinion, has occurred during this Covid hysteria. Never has America had so many immuno-compromised or immuno-suppressed people walking the streets as it does, today. They may be organ transplant recipients, or people with AIDS or others, but they have little, if any, functioning immune systems. There seems to be something very wrong in expecting vaccinations or medications to work the same with these people as they do with the general population. Medical “experts” seem oblivious to this.
Paxlovid is a scary drug; here’s some prescribing information from the FDA EUA PDF:
https://www.fda.gov/media/155050/download
EUA prescribing PDF has this black box warning:
“• PAXLOVID includes ritonavir, a strong CYP3A inhibitor,
which may lead to greater exposure of certain concomitant
medications, resulting in potentially severe, life threatening, or fatal events. (4, 5.1, 7)
• Prior to prescribing PAXLOVID: 1) Review all medications
taken by the patient to assess potential drug-drug
interactions with a strong CYP3A inhibitor like PAXLOVID
and 2) Determine if concomitant medications require a dose
adjustment, interruption, and/or additional monitoring. (7)
• Consider the benefit of PAXLOVID treatment in reducing
hospitalization and death, and whether the risk of potential
drug-drug interactions for an individual patient can be
appropriately managed. (5.1, 7, 14)”
and then there’s this:
“-———————————————CONTRAINDICATIONS-—————
• History of clinically significant hypersensitivity reactions to the active ingredients (nirmatrelvir or ritonavir) or any other components. (4)
• Co-administration with drugs highly dependent on CYP3A for
clearance and for which elevated concentrations are associated with serious and/or life-threatening reactions. (4, 7.3)
• Co-administration with potent CYP3A inducers where significantly reduced nirmatrelvir or ritonavir plasma concentrations may be associated with the potential for loss of virologic response and possible resistance. “
and then the FDA puts this burden on prescribers:
“You or your designee must report all SERIOUS ADVERSE
EVENTS or MEDICATION ERRORS potentially related to PAXLOVID (1) by submitting FDA Form 3500 online, (2) by downloading this form and then submitting by mail or fax, or (3) contacting the FDA at 1-800-FDA-1088 to request this form. Please also provide a copy of this form to Pfizer Inc. at fax number: 1-866-635-8337. (6.4) “
[my comment: since the majority of medications metabolize via the set of CYPA hepatic enzymes, the potential for dangerous and even fatal drug interactions with Paxlovid is enormous ... we elderly are particularly vulnerable to this situation because so many of us have to take multiple medications to stay alive ... folks, even the FDA views Paxlovid as a very dangerous drug ...]