I really want to know the mechanism of this.
Something that causes apoptosis (aka programmed cell death) in any cell with these receptors does not sound safe to me.
Is the apoptosis limited only to cancer cells? I hope so.
Lidocaine induces apoptosis in head and neck squamous cell carcinoma through activation of bitter taste receptor T2R14, Cell Reports (2023). DOI: 10.1016/j.celrep.2023.113437
https://dx.doi.org/10.1016/j.celrep.2023.113437
T2R bitter taste receptors regulate apoptosis and may be associated with survival in head and neck squamous cell carcinoma
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8978516/pdf/MOL2-16-1474.pdf