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Cold temps may help to combat obesity and related metabolic diseases by reducing inflammation, researchers find
Medical Xpress / Joslin Diabetes Center / Nature Metabolism ^ | June 27, 2022 | Satoru Sugimoto et al

Posted on 06/27/2022 8:44:00 PM PDT by ConservativeMind

More than 40 percent of American adults have obesity, a complex condition that can increase the risk of diabetes, cardiovascular disease and certain cancers. One mechanism is by causing low-grade chronic inflammation, the accumulation of immune cells in insulin-sensitive tissues. Scientists hypothesize that reversing—known as resolving—this chronic inflammation could prevent the onset of obesity-related diseases including diabetes and possibly facilitate weight loss.

In a new paper, researchers found that exposure to cold temperatures resolved obesity-induced inflammation while improving insulin sensitivity and glucose tolerance in diet-induced obese mice.

"Extensive evidence indicates that obesity and metabolic syndrome are linked with chronic inflammation that leads to systemic insulin resistance," said Yu-Hua Tseng, Ph.D. "We discovered that cold exposure reduced inflammation and improved metabolism in obesity, mediated at least in part by the activation of brown adipose tissue. These findings suggest a previously unrecognized function of brown adipose tissue in promoting the resolution of inflammation in obesity."

The scientists created a mouse model that becomes obese when fed a typical high-fat, Western diet. When the animals were exposed to a cold environment (around 40 degrees Fahrenheit), the researchers observed that the animals' insulin sensitivity and glucose metabolism improved and their body weight decreased, compared to control animals maintained at a thermoneutral zone—the environmental temperature where the body does not need to produce heat for maintaining its core body temperature. What's more, the scientists also noticed a profound improvement in inflammation, as measured by reduced levels of a major inflammatory marker.

The team notes a shortcut to improved metabolic health may already exist. Multiple human studies conducted at Joslin and elsewhere show that exposure to mild cold temperatures (50 to 55 degrees Fahrenheit) have been shown to be sufficient to activate brown adipose tissue and improve metabolism, though the mechanisms are not well understood.

(Excerpt) Read more at medicalxpress.com ...


TOPICS: Health/Medicine
KEYWORDS:
Time spent in the cold, seemingly with little clothing on, can really impact inflammation, insulin, and glucose issues.

I am reminded of an old NBC News show with Tom Brokaw that showed large men in swimsuits, shivering in a walk-in refrigerator, but having access to all the food they wanted to eat. They all lost weight for the day from simply shivering.

1 posted on 06/27/2022 8:44:00 PM PDT by ConservativeMind
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To: Pete from Shawnee Mission; Mazey; ckilmer; goodnesswins; Jane Long; BusterDog; jy8z; ...

The “Take Charge Of Your Health” Ping List

This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20% fewer pings) or “Everything” list.


2 posted on 06/27/2022 8:44:57 PM PDT by ConservativeMind (Trump: Befuddling Democrats, Republicans, and the Media for the benefit of the US and all mankind.)
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To: ConservativeMind

Well, except for one time in the Summer when I was a kid, I’ve always gotten sick in the Winter months.


3 posted on 06/27/2022 8:48:01 PM PDT by Jamestown1630 ("A Republic, if you can keep it.")
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To: ConservativeMind

“... the typical high fat Western diet”.

They meant to say the typical high carbohydrate Western diet. I’m surprised they got this wrong. Carbs are what make people obese, that’s what is driving the metabolic syndrome, pre-diabetes and full blown diabetes.


4 posted on 06/27/2022 9:11:56 PM PDT by Freedom4US
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To: ConservativeMind
More than 40 percent of American adults have obesity

One does not "have obesity", one is obese. It is a symptom or a condition, not a disease in and of itself. Doctors want to find the cure for the disease when they should be trying to understand the factors causing the condition. I tell people I got my Dad's side of the family, they're all big dudes!

5 posted on 06/27/2022 9:23:03 PM PDT by CtBigPat (The time of Crisis is ending. Now comes Normalization.)
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To: ConservativeMind

Tell this to all the fat Alaskans up here! 😂


6 posted on 06/27/2022 9:39:22 PM PDT by vpintheak (Live free, or die!)
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To: ConservativeMind

eating salads resolves obesity

will miracles ever end


7 posted on 06/27/2022 10:03:00 PM PDT by RomanSoldier19 (Res ad Triarios venit)
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To: ConservativeMind

I KNEW we had more reasons to buy a house in North Idaho! It wasn’t just getting to a friendlier, much more conservative place.


8 posted on 06/27/2022 10:14:36 PM PDT by ProtectOurFreedom (Wanting to make America great isn’t an insult unless you’re trying to make it worse! ULTRAMAGA!!)
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To: ConservativeMind

Visit MN and you will see that this is a lie.
MN packs the pounds on you and very quickly.


9 posted on 06/27/2022 10:16:22 PM PDT by Zathras
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To: vpintheak

Tell this to all the fat Alaskans up here! 😂
———-

Santa Claus could not be reached for comment.


10 posted on 06/27/2022 10:41:31 PM PDT by married21 (As for me and my house, we will serve the Lord.)
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To: CtBigPat

I’m surprised they didn’t write “experiencing obesity”. You know, as if bloating up like the Michelin tire man just sort of falls out of the sky. Could happen to anybody!

Nutrition info generally is often full of weasel words and phrases, I’ve noticed.


11 posted on 06/27/2022 10:55:28 PM PDT by Freedom4US
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To: ConservativeMind

Born an raised in Minnesota. I’ve known
and seen my fair share of women that
we’re moderately obese. Obesity is 80%
genetics. If you want to know what your
new wife is going to look like in 40
years, take good notice of your mother-
in-law. It doesn’t matter what kind of
climate they reside in.
The aforementioned study is pure B.S.


12 posted on 06/27/2022 11:12:55 PM PDT by Lean-Right (Eat More Moose)
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To: ConservativeMind

“Cold temps may help to combat obesity...”

So does eating less... I’ve heard.


13 posted on 06/27/2022 11:17:19 PM PDT by aquila48 (Do not let them make you "care" ! Guilting you is how they control you. )
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To: Jamestown1630

As you know, that’s because many human-infective viruses thrive under those conditions, especially sans abundant UV light. It’s not because your body’s immune system function decreases or something along those lines.


14 posted on 06/27/2022 11:20:55 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: Lean-Right

“The aforementioned study is pure B.S.’

The study is not B.S.; it’s what inferences you draw from it that might be B.S., such as there should be no obese women in cold climates.


15 posted on 06/27/2022 11:23:27 PM PDT by steve86 (Prophecies of Maelmhaedhoc O'Morgair (Latin form: Malachy))
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To: steve86

I guess we’re in agreement then.
I’ve nothing against those that may be
a little on the heavy side. I’m just
saying climate has nothing to do with
how obese one may be. It’s genetics
and a general sense of conscience and
concern of well being.
There are those that are obese from
Argentina to Alaska. Most I know
accept the fact, and just get on with
life. Some obsess and chase that elusive
tail. These are just my humble
opinions, of course.


16 posted on 06/28/2022 12:47:10 AM PDT by Lean-Right (Eat More Moose)
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To: ConservativeMind

OK then. Send fat Liz Cheney to Siberia for the test of her life.
Will do her a lot of good.


17 posted on 06/28/2022 1:38:25 AM PDT by SmokingJoe
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To: ConservativeMind

Thermogenesis for the win, baby!!!! :)


18 posted on 06/28/2022 1:50:10 AM PDT by karatemom (My son is a good man because his father is a good man. )
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To: married21

Oh he’s a “democratic socialist” anyway!


19 posted on 06/28/2022 11:23:30 AM PDT by vpintheak (Live free, or die!)
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