Effects of methyl donors on hippocampal oxidative stress, depression and anxiety (Egg yolk and beet component reversed the damage)

Medical XPress / Neuroscience ^ | Oct. 7, 2021 | Ingrid Fadelli / Sidi Mohamed Coulibaly et al

[ConservativeMind]

Oxidative stress is a condition resulting from an imbalance between the generation of reactive oxygen species and the ability of antioxidants to neutralize those free radicals present in an animal or human's body.

Researchers at have recently carried out a study investigating the potential effects of methyl donor supplementation on oxidative stress in the hippocampus of rats who were administered high amounts of fructose and that displayed depression-like behaviors. Their paper suggests that the administration of methyl donors, nutrients that can cause epigenetic alterations in the body, could be a valuable strategy for treating depression.

"Ours is the first study showing beneficial effects of a diet rich in methyl donors, including folic acid, vitamin B1, cholin[e] and betain[e], in one animal model of depression induced by high fructose feeding," Dr. Adil El Midaoui told Medical Xpress. "We found that daily oral treatment with methyl donors normalized the depression-like behavior, as well as oxidative stress in the hippocampus."

Interestingly, Dr. El Midaoui and his colleagues observed that the rats in the high fructose group presented an increase in oxidative stress markers notably nitrite content and malondialdehyde (MDA) levels within hippocampal tissue. This appeared to be associated with damage caused to neurons in a specific part of the hippocampus.

Nonetheless, the rats who later received methyl donor supplements along with fructose no longer presented oxidative stress in the hippocampus. In addition, their depression-like behavior was normalized (i.e., they no longer exhibited depression-like symptoms).

"Methyl donors reversed the damage observed in the hippocampal neurons with normalization in the plasma levels of glucose, triglycerides, total cholesterol and adipose tissue weight in chronically fructose fed rats," Dr. El Midaoui said. "Hence, methyl donors may be of potential therapeutic value in the treatment of depression."

[ConservativeMind]

Some forms of vitamins have “methyl donor” capability, but to really get a decent amount, you need to eat foods high in it, or supplement with choline (phosphatidyl choline, Alpha-GPC, or citicoline) or with betaine (also known as “trimethylglycine” and “betaine anhydrous”).

The study only used fructose to get the depressive state in place. You may have this state for other reasons, for which the methyl donor substances could still be helpful.

Do note that way overdoing methyl donor foods and supplements can have issues, so take a look at the following two links for more insight.

[ConservativeMind]

Are You Eating Methyl Donor Foods?

https://naturallysavvy.com/eat/are-you-eating-methyl-donor-foods/

Methylation: Why It Matters For Your Immunity, Inflammation & More

https://www.mindbodygreen.com/0-18245/methylation-why-it-matters-for-your-immunity-inflammation-more.html

[deks]

I seem to remember an ad for Super Beets on some show I used to listen to

[sanjuanbob]

Democrats like sugar.

[Taffini]

*

[Taffini]

*

[webstersII]

Isn’t it the case that some people need more of the methyl donor and some need less?

This seems to imply a “one-size-fits-all” approach.

[ConservativeMind]

The two links in the second post can help describe how one might ascertain if they got “too much.”

[BiglyCommentary]

Eggs.

[redinIllinois]

.

[ConservativeMind]

I noticed the links I added weren’t the ones with methyl detriments listed.

Here is one I meant to post:

https://kresserinstitute.com/treating-methylation-supplementing/