Well, KE is KE. Hole size destroys tissue, damaged tissue bleeds, blood loss ends life. Bigger holes in the same organs bleed more etc.
Comparing a 90 grain 30 cal to. 230 45 cal is apples and oranges when it comes to tissue disruption.
Hydrostatic/temporary cavity has been proven to be not a major wounding mechanism as once thought.
Permanent cavity is what kills.
Of course, any bullet to the CNS is likely to stop/kill.
As for me, 40 or 45 is my choice.
Carry on.