It is possible the weight loss is a result of his role in Richard Says Goodbye, where Depp plays the titular character who decides to live life to the fullest after doctors diagnose him with a terminal illness.
So you’re saying that he’s looking sick because he’s playing a sick man?
Nahhhh, couldn’t be.
After all, the FR bwahnahs have declared otherwise!
Or he’s been getting blood transfusions from Keith Richards in a plan to live forever