My issue with all (that I have tried) versions of Linux is getting Wine to run my Windows programs well.
There are just some things that aren’t produced with Linux in mind.
Is there a version that does better using Wine that others?
My first question is what Windows programs are you trying to run?
Which version of WINE?
I have a Windows program (Caligari Truespace) that I got to run by installing a newer version of WINE and running one actual Windows DLL.