[Billthedrill]

Depends on the pocket, I guess. I carried a Glock 42 for a few days and found it pretty comfortable, IF you use a pocket holster. Both the Ruger LCP and the S&W Bodyguard have fans in the .380 arena. With modern ammunition the .380 is...well, better than it used to be. You won't be taking on tanks with it.

Personally I prefer a small 9mm - a Kahr PM-9, a Kimber Micro 9 (I own and carry those) or a Sig P938, the latter two if you like the quasi-1911 controls. These are a little bulkier than their .380 counterparts but I do like 9mm. All of the above I have experience with; there are lots more in that very popular category. YMMV.

[Defenestrator]

I pocket carry Kahr PM9. The Kahr P380 is tiny compared to the 9, and easy to shoot imho.