I think Depp’s biggest problem is that he is too fond of working with Tim Burton, basically willing to go along with any kooky project that Burton dreams up, whether it will make money or not.
Plus, despite being handsome, Depp is just not the traditional leading man type that tends to carry big budget movies. He’s too much of an oddball at heart, and he really does his best in oddball roles.
Depp has the right persona for the Alice fantasies. The problem is that the dreck that was produced has NOTHING in common with the Lewis Carroll books.