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I would say two things: 1) some of the things he claims are paradoxes aren't. They're pretty well understood and he just doesn't understand them, and 2) there are things that we don't know, because we don't have a Quantum Theory of Gravity. Those aren't necessarily paradoxical per se: we just don't know. In order to kinda sorta get to something like what's happening, we patch together Quantum Mechanics and General Relativity as best we can, and it gets some good results. But there are surely conceptual and fundamental surprises waiting.

Full disclosure: I was once a physicist. I am not one anymore. I've tried to keep my hand in as an interested layperson, but my specialty was never Cosmology or Particle Physics. When I was a scientist I was a Condensed Matter Theorist. That was long ago.

That said, I'm not as sanguine as some people that we are "very close" to a Theory of Everything. There still seems like a very great deal of work to do. Including some VERY BIG ideas that we don't yet have.

I went to the Einstein Planetarium at the Air & Space Museum in Washington DC for a star & galaxy show. The show was called the Dark Universe. Only by dark they meant unknown. That is they tried to show that we don’t actually know what 95% of the matter and energy is out there. And what our telescopes can “see” of the universe is only a tiny fraction of what’s out there.

It was pretty wild.

About like an updated version of 14h century maps which showed europe and asia and oceans in which dragons dwelled.

Including some VERY BIG ideas that we don’t yet have.
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The 1890’s were about 10-20 years before Einstein’s work. It seems to me I’ve read articles that suggested that scientists of the day were seeing too many things that didn’t fit the then standard model. So they thought a paradigms shift was just over the horizon. And so it was.

Do you see a paradigm shift coming in the nest 10—20 years.