I first saw a photo of the Horsehead Nebula in grade school more than fifty years ago.
No change. Must be larger than even our ability to imagine. Awesome.
It is immense, about two light years across (from nose to mane). You generally won’t see significant changes to something like that in a human lifespan, except perhaps for the occasional new star lighting up inside a nebula (for example, McNeil’s nebula http://en.wikipedia.org/wiki/McNeil%27s_Nebula ). To see huge structures like this change rapidly enough to observe the change in human timespans, you have to look at something moving with relativistic velocities, such as a black hole jet. M87’s black hole jet is a good example of this and can be seen at the end of this video:
https://www.youtube.com/watch?v=dIISjVeIYTw