I have been saying for quite some time that the campaign trail will kill her. She is VERY frail (moreso than people think).
The only problem with that is we might end up with fauxahontus.
I'm firmly convinced that if we have a strong conservative candidate in 2016 Lizzie Warren or any other dem will get crushed in the election. Unlike 2012, Obama's numbers are underwater and he'll be an absolute drag on his party, think of GWB in 2008.