Proper placement is of paramount importance with the .22 It can be VERY deadly. High speed solids would get my vote.
Saw a youtube vid where the guy wrapped a 5 pound roast in 4 layers of denim and filled it full of 22LR at 300 yards. Food for thought....pun intended.
A good 22 semi-auto rifle is just a great thing to have.
I have a Remington Nylon 66 I bought 35 years ago, tube loader limits it somewhat, but damn it is a fun gun to shoot. Lighter than my Crossman pellet gun.