A .22 to the head is usually a game changer as it likes to ricochet around the inside of the skull.Also remember you only want to deal with the situation in your home, not your neighbors. Pick the gun and caliber for your surroundings.
Vincent ‘Vinnie’ Antonelli (My Blue Heaven): “Richie loved to use 22s because the bullets are small and they don’t come out the other end like a 45. See, a 45 will blow a barn door out the back of your head and there’s a lot of dry cleaning involved, but a 22 will just rattle around like Pac-Man until you’re dead. “