.380 aren’t all that bad. They’ve got pretty much the same caliber as a 9mm, just not as much powder behind it. Range vs shot placement are the two biggest factors there. Chances are if a woman needs it, it’s going to be at point blank range to very short range.
About the Glock though look into a 9mm Springfield XD or some other brand. Your wife’s problem with the Glock recoil may actually be due to the larger grips on a Glock and not really the recoil of the round.
Stay away from the .25, quite possibly the worst round ever made. You’re better off with a pistol that shoots .22lr.
I agree with the recommendation about the Springfield XDm 9mm. I am a woman with a small hand and have no problems with my Springfield. The XDm comes with small, medium and large backstraps, and are fairly easy to switch out. I installed the small backstrap and it fits perfectly in my hand. No problems with recoil. I could shoot that gun all day without a lot of fatigue, and that’s saying something because I have had arthritis surgery on both hands over the past two years.