Posted on 12/05/2010 11:16:07 AM PST by decimon
Damage caused by multiple sclerosis could be reversed by activating stem cells that can repair injury in the central nervous system, a study has shown.
Researchers from the Universities of Cambridge and Edinburgh have identified a mechanism essential for regenerating insulating layers – known as myelin sheaths – that protect nerve fibres in the brain. In additional studies in rodents, they showed how this mechanism can be exploited to make the brain's own stem cells better able to regenerate new myelin.
In multiple sclerosis, loss of myelin leads to the nerve fibres in the brain becoming damaged. These nerve fibres are important as they send messages to other parts of the body.
The scientists believe that this research will help in identifying drugs to encourage myelin repair in multiple sclerosis patients.
Professor Robin Franklin, Director of the MS Society's Cambridge Centre for Myelin Repair at the University of Cambridge, said: "Therapies that repair damage are the missing link in treating multiple sclerosis. In this study we have identified a means by which the brain's own stem cells can be encouraged to undertake this repair, opening up the possibility of a new regenerative medicine for this devastating disease."
The study, funded by the MS Society in the UK and the National Multiple Sclerosis Society in America, is published in Nature Neuroscience.
Professor Charles ffrench-Constant, of the University of Edinburgh's MS Society Centre for Multiple Sclerosis Research, said: "The aim of our research is to slow the progression of multiple sclerosis with the eventual aim of stopping and reversing it. This discovery is very exciting as it could potentially pave the way to find drugs that could help repair damage caused to the important layers that protect nerve cells in the brain."
Multiple sclerosis affects almost 100,000 people in the UK and several million worldwide. It often targets young adults between the ages of 20 and 40.
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For more information please contact:
Genevieve Maul, Office of Communications, University of Cambridge Tel: direct, +44 (0) 1223 765542, +44 (0) 1223 332300, Mob: +44 (0) 7774 017464 Email: Genevieve.maul@admin.cam.ac.uk
Catriona Kelly, Press and PR Office, University of Edinburgh Tel 0131 651 4401; Mobile, 07979 446 209; catriona.kelly@ed.ac.uk
Notes to Editors:
1. The paper 'Retinoid X receptor gamma signaling accelerates CNS remyelination' will be published in the 05 December 2010 edition of Nature Neuroscience.
2. For reaction to this research from the MS Society, please call Jenna Litchfield in the MS Society press office on 07798 631674.
3. A picture of nerve fibres in rodents showing remyelination can be downloaded from http://jalbum.net/a/829951/ password: nervefibres
4. The MS Society is the UK's largest charity supporting people affected by multiple sclerosis.
Ping
FASTER, PLEASE.
MS has been curable for 35 years or more:
http://www.tldp.com/issue/11_00/klenner.htm
http://www.doctoryourself.com/klennerbio.html
There must be quite a list of people cured.
Once again, the justification for embryonic stem cells sufferes a discrediting blow.
CORRECTION: sufferes = suffers
“MS has been curable for 35 years or more:”
“There must be quite a list of people cured.”
So far as I know, no one is keeping track, since the medicine of Dr. Fred R Klenner has never been either accepted or refuted by the mainstream medical establishment.
Dr Fred Klenner was a Duke University Medical School graduate, and Fellow: The American College of Chest Physicians; Fellow & Diplomate: The International College of Applied Nutrition; Fellow: The American Association for the Advancment of Science; Fellow: The American College of Angiology; Fellow: The American Academy of Family Practice; Fellow: The Royal Society of Health (London); Fellow (Honorary): The International Academy of Preventive and Orthomolecular Medicine; Fellow: International College of Angiology; and Founder-Fellow: American Geriatrics Society.
In his paper Dr. Klenner had this to say:
“We categorically make this statement: Any victim of Multiple Sclerosis who will dramatically flush with the use of nicotinic acid, and who has not yet progressed to the stage of myelin degeneration, as witnessed by sustained ankle clonus elicited in the orthodox manner, can be cured with the adequate employment of Thiamin Hydrochloride and other factors of the Vitamin B Complex in conjunction with essential proteins, lipids, carbohydrates and injectable crude liver.”
From the BBC article on this: "But they cautioned it would be some years before treatments were developed."
http://www.bbc.co.uk/news/health-11913689
Seems that all these stories carry that disclaimer.
“The sound barrier was broken in 1947. The Korean War began in 1950. In between was the polio epidemic of 1948-9, during which Dr. Frederick Robert Klenner cured every polio case he saw by using vitamin C.”
There are some pretty wild claims being made at that site.
“There are some pretty wild claims being made at that site.”
It certainly is wild that Dr Klenner’s work has largely been ignored for 60+ years.
It only took 20 years for Joseph Lister to prove Ignaz Semmelweis, who had died 2 years earlier in an insane asylum, correct. In 1969 the largest and oldest medical school in Hungary was renamed Semmelweis University.
I wonder how long it will be before a medical school is named after Fred Klenner? Almost certainly not in my lifetime.
“Hear now this, O foolish people, and without understanding; which have eyes, and see not; which have ears, and hear not”
Jeremiah 5:21
http://www.seanet.com/~alexs/ascorbate/198x/smith-lh-clinical_guide_1988.htm
Your second link is interesting. It prescribes “Pyridoxine (B-6): “100 mg to 200 mg is given before meals and bed hour.” This would result in extreme nightmares, unless the person was deficient in Magnesium.
Retinoid X receptor gamma signaling accelerates CNS remyelination
A trial of 9-cis-retinoic acid might not be far away.
BTTT
“This would result in extreme nightmares”
Would I even dream that Obama is President?
B6 is known to stimulate vivid dreams (pleasant and unpleasant), and some people even unwisely use it as a legal recreational drug. B6 in overdose is certainly toxic. I don’t know if this was not known in the 1940s, or if the combination of vitamins used by Dr Klenner eliminated the toxicity. This whole area of medicine deserves a lot more attention and research, not deliberate avoidance.
I agree. Unfortunately, following the money trail doesn't lead to such inexpensive treatments.
great news.. I hope this helps many people.
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