Generally speaking a heavier bullet gives more penetration than a lighter bullet.
Generally speaking a faster bullet gives more penetration than a lighter bullet.
Generally speaking.
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Of the same weight and velocity two different diameter bullets the smaller diameter bullet penetrates further.
Of course there are other factors like how the bullet is constructed which could give more or less expansion, if any. A bullet that bumps up quickly will slow the bullet down faster, imparting more knockdown energy.
If a bullet passes threw a target without expansion it leaves a pencil hole clear through. If its through the vitals youre dead. If a bullet expands rapidly in the vitals youve dead quicker but still dead. If a bullet expands upon impact (varment loads) on a large target like a human. It imparts all its energy right that away and knocks you down. But if it doesnt hit the vitals you probably will survive it.
I could go on.