He accurately identifies the causes of the discontent. Where is the power to be lodged. Who is to wield it's patronage? Where is the Wealth to be concentrated?
These are exactly correct, and the answer as we have all come to realize, is "New York/Washington."
More or less the same problem we are facing today.
That's only because you know nothing of real history.
In fact, because of the Constitution's 3/5 rule among other reasons, US political power from 1788 to 1860 was centered on Southern Democrats, often by huge majorities.
So nothing happened they seriously opposed, and what they seriously wanted, they eventually got.
Pick any example: SCOTUS 1857 Dred Scott decision.
Yes, that might have changed after the 1860 election, but Deep South Fire Eaters never stuck around long enough to find out.
Having potentially lost control for the first time ever, they immediately bolted for the doors, without waiting for any actual negative consequences.