I think that is entirely in the eye of the beholder. George III thought he was perfectly reasonable with the colonists. The Colonists did not.
I think the Confederates probably didn't like the fact that their 1/4th of the citizens were paying 3/4ths the cost of the government, while at the same time New York Shipping, banking, warehousing and insurance industries were siphoning off about 40% of their profits.
In their eyes, the government had become contrary to their best interests and therefore "destructive of these ends."
Regardless of how often you repeat that, it's still rubbish, every word of it.
First of all none of the early seceding states complained about tariffs, shippers or New York bankers in their "Reasons for Secession" documents.
All focused instead on their real reason: fear that abolitionist "Ape" Lincoln and his Black Republicans would challenge their "peculiar institution", slavery.
They declared secession to protect slavery.
Second of all, your statistics are woefully wrong: 1/4 of US citizens did not produce any exports.
Virtually all of those cotton, sugar & rice exports were produced by 3.5 million non-citizens = slaves.
Third, those Deep South slaves produced about 1/2, not 3/4 of US exports.
The rest of "Southern Exports" actually came from Upper South and Border State regions which remained loyal to the Union.
So those were "Union Exports" not Confederate.
Fourth, those allegedly wicked New Yorkers who took "40% of their profits" transported only 20% of the entire cotton crop.
The rest, 80%, shipped from Gulf Coast ports like New Orleans directly to their European customers.
Which ships they used, and who owned those ships, were totally matters of the cotton producers' choices.
DiogenesLamp: "In their eyes, the government had become contrary to their best interests and therefore 'destructive of these ends.' "
In fact the US Federal government had been under iron grip control of the Southern Slave-Power since Day One of the Republic.
It happily did what the Slave-Power demanded in most matters.
And in November 1860 nothing changed except the election of abolitionist "Ape" Lincoln and his Black Republicans.
Republicans did not even take office -- Southern & Doughfaced Democrats like President Buchanan were still firmly in charge.
So Deep South Fire Eaters declared their secession "at pleasure", and that made it unconstitutional in the eyes of every unionist.