I live out in the sticks. My first zone of security starts at about 500 yards. Second is about 100 yards. Somewhere after that comes dogs, pistols and hand to hand.
So waxing shotgun rounds is kind of a non-starter. For 500 yards, I’d be a big fan of a .50 cal. 100 yards, a .30-06.
For anything shorter than that, I would use passive defenses since they are likely using armor, like an MRAP. A backhoe some cheap wood and some time can make an MRAP pretty useless. Of course if you disable their toy, they’ll prolly send in a Reaper and nick you with a Hellfire.