I guess it would be a bad day. Same thing if a hundred volcanoes erupted or huge earthquakes or maybe fire from heaven.
I think the panhandle is some of the most geologically stable areas in the world.
The main danger is from across the ocean, La Palma volcano in the Canary Islands. It is possible a massive slab could fall into the ocean and trigger a tsunami that would still be 50 meters high when it hit Floriduh.