Liz Cheney’s run isn’t going to cripple the Republican party in Wyoming. Whoever wins the nomination will win in the general election. What it will do is tell every sitting senator that no matter how conservative you are there will always be someone willing to be a carpetbagger and run against you with buckets of outside money.
No, Simpson was the disaster. He was elected to represent one of the most conservative states in America, then threw social conservatives under the bus. That's why he is a former senator.
The nicest thing you can say about him is that he didn't quite stoop to the level of Chuck Hagel.
The disaster moniker is hyperbolic in a Cheney vs. Enzi contest. It should be reserved for people like McCain, Graham, Hagle or Simpson who throw their base under the bus in return for meaningless accolades from the left.