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An international research team focused on aging reports that urolithin A at 1,000 mg per day shifted human immune profiles toward a more naive-like, less exhausted CD8+ state and increased fatty acid oxidation capacity, with additional functional gains. Urolithin A is a metabolite produced naturally through microbial digestionin much smaller quantities than available as a supplement or used in the study. Aging bodies face reduced production of mature T cells, shrinking naive T cell pools and chronic low-grade inflammation. Mitochondrial dysfunction and waning autophagy sit at the core of these shifts, with mitophagy failure linked to immune dysregulation and disease....

mRNA vaccines cause myocarditis by leading your own immune cells to attack your heart, which can lead to sudden death by ventricular tachycardia or fibrillation. ... Medical pathologists from Heidelberg University Hospital in Heidelberg, Germany have published direct evidence showing how people found dead after mRNA vaccination died. As this team of six scientists explore in their study, these mRNA-vaccinated patients suffered from heart damage because their hearts were attacked by their own immune cells. This autoimmune attack on their own heart cells then leads to their damaged hearts beating so many times per second that, once the tachycardia unexpectedly...

New research from the University of East Anglia and Quadram Institute reveals how our immune cells use the body’s fat stores to fight infection. The research, published today (December 8, 2021) in the journal Nature Communications, could help develop new approaches to treating people with bacterial infections. The research team says their work could one day help treat infections in vulnerable and older people. The team studied Salmonella — a bacterial infection that causes diarrhea, vomiting, abdominal pain, fever, and sepsis. The UEA team collaborated with the Quadram Institute and colleagues at the Earlham Institute, to track fatty acid movement...

An experimental Ebola vaccine appears safe and triggered signs of immune protection in the first 20 volunteers to test it, U.S. researchers reported Wednesday. The vaccine is designed to spur the immune system's production of anti-Ebola antibodies, and people developed them within four weeks of getting the shots at the National Institutes of Health. Half of the test group received a higher-dose shot, and those people produced more antibodies, said the study published in the New England Journal of Medicine. Some people also developed a different set of virus-fighting immune cells, named T cells, the study found.

Very soon, perhaps in a few days or weeks, someone in the United States will injure his or her spinal cord and become paralyzed. They may crash their car, slip on ice or fall at a job site. UMDNJ is one of three sites nationally that is testing specially treated immune cells -- called macrophages -- that are injected into the spinal cord. The treatment may not help patients walk, but they may be able to regain sensations or recover some movement. Proponents want to open new avenues of research, and counter thinking that the spinal cord can never be...

By Maggie Fox, Health and Science Correspondent WASHINGTON (Reuters) - Scientists said on Tuesday they had transformed ordinary human skin cells into immune cells in an experiment that, if it can be repeated, might bypass the need for either stem cells or highly controversial cloning technology for many medical therapies. The team at biotech start-up Nucleotech LLC hope to be able to offer patients grow-your-own transplants that could theoretically be used to treat diseases such as immune deficiencies and juvenile diabetes. Many teams are working on the idea, but nearly all had assumed the need for stem cells, the body's...