Alexander the Great's Death Debated Aug. 2, 2004 — What killed ancient world conqueror Alexander the Great is still a mystery, pitting scientists who favor West Nile virus against those who lean toward a death from typhoid. History says that Alexander, king of Macedonia, died at 32 in 323 B.C. after several days of fever in Babylon. However, the cause of the fever was always unclear.Alexander In The Fog Several hypotheses have been advanced: poisoning, malaria, or cirrhosis of the liver caused by Alexander's penchant for drink, as well as typhoid or west Nile virus. “ The dispute resurfaced in...