....Researchers from the GenOMICC consortium compared the 2,700 ICU patients’ genetic information with samples from healthy volunteers from other studies. They discovered key differences in these five genes: IFNAR2, TYK2, OAS1, DPP9, and CCR. They “partially explain why some people become severely sick with Covid-19, while others are not affected.” “Our findings reveal that critical illness in Covid-19 is related to at least two biological mechanisms: innate antiviral defenses, which are known to be important early in disease (IFNAR2 and OAS genes), and host-driven inflammatory lung injury, which is a key mechanism of late, life-threatening COVID-19 (DPP9, TYK2, and CCR2),”...