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Vladimir Putin 'DOES have Parkinson's and pancreatic cancer, leaked Kremlin spy documents claim'
11/01/2022 2:29:46 PM PDT · by marcusmaximus · 65 replies
Daily Mail ^ | 11/11/2022 | Jack Newman
Vladimir Putin does have early stage Parkinson's disease and pancreatic cancer, leaked spy documents have alleged in the latest unverified claim about the tyrant's ill health. The Russian leader has been plagued with rumours about his illnesses for months and he has regularly appeared twitching and unsteady in public, sparking hope in Ukraine and the West the despot could soon relinquish power. Claims have been circulating among opposition figures, fuelled by his unexplained absences and his shaky public appearances, that he is battling serious health problems but they have always been rubbished by the Kremlin. -snip- 'Putin is regularly stuffed...

Zinc enhances albumin's protective role against Parkinson's disease (Extra zinc and alpha lipoic acid help)
10/17/2022 7:51:02 PM PDT · by ConservativeMind · 3 replies
Medical Xpress / King Abdullah Univ. of Sci. and Tech. / Intl. Jrnl. of Biological Macromolecules ^ | Oct. 17, 2022 | Samah Al-Harthi et al
Revealing zinc's interaction with a critical transport protein underscores the need to study biological pathways under physiologically relevant conditions. Heavy metals in the body have long been thought to induce the aggregation of disease-linked proteins, but a study shows this is not always the case. It turns out that zinc ions tune the ability of human serum albumin (HSA), an abundant transport protein in the body, to better prevent α-synuclein from aggregating, a process directly linked to Parkinson's disease. The finding should "open new avenues for preventive treatments," says Samah Al-Harthi, a Ph.D. student. The unexpected role for zinc discovered...

Scientists may have found way to clear the brain of toxic chemicals responsible for brain diseases like Alzheimer's and Parkinson's - but it's already too late if you've got it
08/24/2022 11:07:59 AM PDT · by RummyChick · 29 replies
daily mail ^ | 8/24/2022 | andrews
A research team may have found a new way to clear harmful proteins in the brain that trigger cognitive diseases like Alzheimer's and Parkinson's, opening the door for new treatments for the devastating conditions. Experts believe that Alzheimer's is triggered by amyloid beta proteins building up in the brain and clumping together, triggering tell-tale symptoms such as memory loss and loss of general cognitive function. Research from the Washington University School of Medicine in St. Louis, Missouri, found that ramping up levels of a separate protein — aquaporin 4 — could help to remove them. In a study on mice...

Treadmill exercise shown to improve Parkinson's symptoms in mice (Fenofibrate also helped)
08/21/2022 2:31:49 PM PDT · by ConservativeMind · 10 replies
Medical Xpress / Rush University Medical Center / Cell Reports ^ | August 18, 2022 | Debashis Dutta et al
Regular treadmill exercise helped improve Parkinson's disease symptoms in mice in a recent study. Scientists found positive results in using exercise to stop the spread of the α-synuclein protein and reverse biochemical, cellular, and anatomical changes that occur in the brains of mice with Parkinson's disease in the absence of drugs. The mice ran on a treadmill consistently in 30-minute intervals for six days a week, over two months. Pahan and his team were quick to note while treadmill exercise is something that can be easily available and accessible, some patients with Parkinson's might not be able to run on...

Copper leads to protein aggregation in Parkinson's disease
07/08/2022 7:15:09 PM PDT · by ConservativeMind · 5 replies
Medical Xpress / Swiss Federal Laboratories for Materials / ACS Chemical Neuroscience ^ | July 7, 2022 | Rainer Klose / Olena Synhaivska et al
Copper exposure in the environment and the protein alpha-synuclein in the human brain could play an important role in the pathogenesis of Parkinson's disease. A team from was able to show how the protein forms into an unusual shape when exposed to large amounts of copper ions. Researchers have now taken a closer look at the abnormal shape of these alpha-synucleins in the form of protein rings. In doing so, they were also able to visualize at the nanoscale the connection with environmental pollution by copper. The researchers are targeting a protein that is involved in several molecular processes in...

The tell-tale tremor of a doomed tyrant: How Putin's 'uncontrollable' shaking hand bears the hallmarks of Hitler's Parkinson's disease... as Allied forces closed in on Berlin in 1945
04/27/2022 9:09:24 AM PDT · by marcusmaximus · 57 replies
Daily Mail ^ | 4/27/2022 | Harry Howard
Amid rumours about his poor health, a video showing Vladimir Putin's shaking hand as he greeted Belarus's leader resurfaced this week. The clip, which was filmed just before Russia's invasion of Ukraine in February, showed him gripping a chair and pressing his hand to his chest to stop it shaking as he greeted Alexander Lukashenko. It fueled further speculation of the state of his health after footage and images appeared to show his bloated face and slouching posture. But the scenes of Putin's apparent struggles are reminiscent of a clip that showed Adolf Hitler's own failing health as Germany faced...

Parkinson's Benefitted by a Special Diet (Lower carb Mediterranean diet with wheat germ & strawberries stops/reverses progression for 4+ years)
03/15/2022 8:32:53 AM PDT · by ConservativeMind · 17 replies
NewsMax / Journal of Medicinal Food ^ | Feb. 22, 2022 | Russell Blaylock, M.D. / Virginia V Renoudet, et al
A startling report details a single case of a 53-year-old woman who had moderately advanced Parkinson’s disease. Her motor symptoms — cogwheel rigidity, micrographia, bradykinesia, dystonia, reduced arm swing, and retropulsion, all classical signs of Parkinson’s disease — improved rather dramatically. She also experienced significant improvement in dressing, showering, walking, conversing, climbing stairs, gardening, typing, and writing. And she did this by following a special diet rather than taking medications. Her disease was diagnosed in the year 2000 by two neurologists, one of whom was a medical center specialist. She started her special diet eight years later, and her symptoms...

2 rheumatoid arthritis drugs tied to lower risk of Parkinson's (HCQ and chloroquine reduced risk 26%)
01/29/2022 6:53:10 PM PST · by ConservativeMind · 6 replies
Medical Xpress / Neurology / HealthDay ^ | Jan. 28, 2022 | Anne Paakinaho et al
Two rheumatoid arthritis drugs show potential for lowering the risk of Parkinson's disease, new research shows. Some previous studies have found that people with rheumatoid arthritis have a lower risk of Parkinson's, and it was suggested that a class of rheumatoid arthritis drugs called disease-modifying antirheumatic drugs (DMARDs) may play a role in that reduced risk. To learn more, researchers analyzed data from thousands of patients in Finland. The use of most DMARDs—including methotrexate, sulfasalazine, gold preparations or immunosuppressants—at least three years before Parkinson's disease diagnosis was not associated with the risk of the disease in those with rheumatoid arthritis,...

Study could explain why Parkinson's drug improves, then diminishes quality of life (L-dopa l, a protein, and iron create cellular iron overload/oxidation)
01/20/2022 9:13:55 AM PST · by ConservativeMind · 7 replies
Medical Xpress / ACS Chemical Neuroscience / University of California, Irvine ^ | Jan. 20, 2022 | Sammy Alhassen et al
A team of researchers has discovered a possible reason why L-dopa, the front-line drug for treating Parkinson's disease, loses efficacy and causes dyskinesia—involuntary, erratic muscle movements of the patient's face, arms, legs and torso—as treatment progresses. "Paradoxically, the exact therapy that improved the quality of life for tens of thousands of Parkinson's patients is the one that contributes to the rapid decline in quality of life over time," said Amal Alachkar, Ph.D. "L-dopa has been shown to accelerate disease progression through neural mechanisms that are not very well understood." L-dopa and other pharmacological treatments for Parkinson's are designed to replace...

Combination therapy reduces toxic aggregates in Parkinson's disease (diltiazem (a calcium channel blocker))
11/30/2021 2:10:46 PM PST · by ConservativeMind · 6 replies
Medical XPress / Northwestern University / Neuron ^ | Nov. 24, 2021 | Will Doss / Iva Stojkovska et al
A new combination of drugs could fix the broken lysosomal enzyme pathway in Parkinson's disease-afflicted brain cells. Improving transport of these enzymes can boost lysosomal function, aiding the cellular organelle in breaking down harmful protein aggregates that are a primary cause of symptoms in Parkinson's disease (PD), according to Joseph Mazzulli, Ph.D. "We think moving forward, these combination therapies would be very effective," Mazzulli said. A defining characteristic of PD is the accumulation of misfolded alpha-synuclein proteins in the brain. These proteins aggregate and form clumps which are linked to a variety of harmful effects including oxidative stress, inflammation and...

Vascular defects appear to underlie the progression of Parkinson's disease (Nilotinib stopped progression)
11/22/2021 7:38:11 PM PST · by ConservativeMind · 9 replies
Medical XPress / Neurology Genetics ^ | Nov. 12, 2021 | Charbel Moussa, MBBS, Ph.D. et al
In an unexpected discovery, researchers have identified what appears to be a significant vascular defect in patients with moderately severe Parkinson's disease. The finding could help explain an earlier outcome of the same study, in which the drug nilotinib was able to halt motor and non-motor (cognition and quality of life) decline in the long term. The researchers say their finding suggests that blood vessel walls called the blood brain barrier, which normally act as a crucial filter to protect the brain against toxins as well as allow passage of nutrients to nourish it, doesn't work correctly in some Parkinson's...

Study links diabetes medications to glaucoma prevention (Also Alzheimer's and Parkinson's diseases through blood sugar receptor)
09/20/2021 1:34:42 PM PDT · by ConservativeMind · 12 replies
Medical XPress / Perelman School of Med. at the Univ. of Penn. / British Journal of Ophthalmology ^ | Sept. 20, 2021 | Jacob Sterling et al
A popular class of diabetes medications called GLP-1R agonists (Trulicity and Rybelsus) may also protect against glaucoma in diabetic patients, according to a new study led by researchers in the Scheie Eye Institute at the University of Pennsylvania's Perelman School of Medicine. The findings were published in the British Journal of Ophthalmology. The researchers looked at retrospective data of 1,961 diabetic patients who were new users of this class of drugs and matched them to 4,371 unexposed control subjects. After 150 days on average, 10 patients in the medicated group were newly diagnosed with glaucoma (0.5 percent) compared to 58...

Parkinson's, cancer, type 2 diabetes share a key element that drives disease
04/07/2021 12:58:38 PM PDT · by Red Badger · 9 replies ^ | 07 April 2021 | by Salk Institute
Parkin protein (green signal) is in a different part of the cell than the mitochondria (red signal) at time 0 (left image) but then co-localizes with the mitochondria after 60 minutes (right image). Credit: Salk Institute ======================================== When cells are stressed, chemical alarms go off, setting in motion a flurry of activity that protects the cell's most important players. During the rush, a protein called Parkin hurries to protect the mitochondria, the power stations that generate energy for the cell. Now Salk researchers have discovered a direct link between a master sensor of cell stress and Parkin itself. The same...

Parkinson's dyskinesia mechanism explained
05/04/2020 5:45:36 AM PDT · by zeestephen · 7 replies
Science Daily ^ | 01 May 2020
Many people with Parkinson's disease eventually develop debilitating movements called dyskinesia, a side effect of their much-needed dopamine replacement medication. The mechanism underlying this unwanted side effect has been unknown, until now. An international collaboration led by Scripps Research, Florida has found a key cause, and with it, potentially, a new route to providing relief.

Ozzy Osbourne Diagnosed with Parkinson's Disease
01/22/2020 7:39:19 PM PST · by wastedyears · 70 replies ^ | 1/21/2020 | Philip Trapp
On Tuesday (Jan. 21), Ozzy Osbourne shocked the rock world by revealing his recent diagnosis with Parkinson's disease, a long-term degenerative disorder of the central nervous system. The news comes after a string of health woes throughout 2019 pushed back the singer's tour dates across the world.

Waking up dormant dopaminergic neurons to reverse Parkinson's disease (Reverse early Parkinson’s)
01/09/2020 9:06:28 PM PST · by ConservativeMind · 8 replies
Institute for Basic Science ^ | January 9, 2020 | Many
As many as seven to 10 million people in the world are thought to live with Parkinson's disease (PD). Current medical treatments for PD rely on alleviating PD symptoms with little efforts to explore ways to reverse the symptoms. It is firmly believed that abnormal movements of PD begin in the brain where the production of dopamine, a neurotransmitter for movement control, is irreversibly impaired. Currently, L-DOPA, a potent PD medication is mainly prescribed to replenish dopamine in the deprived brain. However, such treatment is symptomatic, not disease-modifying therapy. The researchers reported that the symptoms of PD begin when dopaminergic...

Parkinson's Patients are Mysteriously Losing the Ability to Swim After Treatment
11/27/2019 6:51:49 PM PST · by BenLurkin · 22 replies
Discover Magazine ^ | November 27, 2019 1:00 PM | By Jennifer Walter
For Parkinson’s patients, deep brain stimulation (DBS) can help control a number of neurological symptoms, like muscle spasms and stiffness. But one weird side effect has surfaced in a string of case studies: Some patients, no matter how good their motor skills, lose their ability to swim after the procedure. Researchers from the University of Zürich in Switzerland published a report today in Neurology identifying nine cases where patients couldn’t stay afloat after DBS. And these people weren’t water-shy, first time doggie paddlers — two of the cases involved former competitive swimmers. And, researchers report, the entire cohort had had...

Japan team transplants stem cells into brain to treat Parkinson's
11/10/2018 6:36:21 PM PST · by Olog-hai · 23 replies
Agence France-Presse ^ | 9 Nov 2018
Japanese researchers said Friday they have transplanted stem cells into the brain of a patient in the first stage of an innovative trial to cure Parkinson’s disease. The research team at Kyoto University injected induced Pluripotent Stem (iPS) cells — which have the potential to develop into any cell in the body — into the brain of a male patient in his fifties, the university said in a press release. The man was stable after the operation, which was performed last month, and he will now be monitored for two years, the university added. The researchers injected 2.4 million iPS...

Brain implants used to treat Parkinson's can be hacked and used to control people, scientists warn
11/01/2018 3:23:13 AM PDT · by SkyPilot · 32 replies
Telegraph ^ | 31 Oct 18 | Natasha Bernal
Brain implants used to treat Parkinson's disease could be hacked by cyber attackers and used to control people, scientists have claimed. A report by the Oxford Functional Neurosurgery Group and cyber security company Kaspersky claims that people's memories could be exploited by hackers and has called on cyber security companies, manufacturers and healthcare companies to develop new technology to stop them. Academics have previously warned that brain implants could prevent patients from "speaking or moving, cause irreversible damage to their brain, or even worse, be life-threatening". They claimed that hackers could overload or disable the system, and could damage...

Alan Alda reveals he has Parkinson's disease: "I'm not angry"
07/31/2018 11:33:42 AM PDT · by 2ndDivisionVet · 33 replies
CBS News ^ | July 31, 2018 | Jessica Kegu
Alan Alda has Parkinson's disease. In an appearance on "CBS This Morning" Tuesday, the award-winning actor, best known for his relatable portrayal of Army Capt. "Hawkeye" Pierce in the TV series "M*A*S*H," revealed he was diagnosed three-and-a-half years ago. "I've had a full life since then," he said. "I've acted, I've given talks, I help at the Alda Center for Communicating Science at Stony Brook. I started this new podcast. And I noticed that – I had been on television a lot in the last couple of weeks talking about the new podcast – and I could see my thumb...
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