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Parkinson's medication improved blood pressure in teens with Type 1 diabetes (Bromocriptine/Parlodel)
12/06/2022 7:15:57 PM PST · by ConservativeMind · 3 replies
Medical Xpress / American Heart Association / Hypertension ^ | Dec. 6, 2022 | Michal Schäfer, Ph.D.
Teens with Type 1 diabetes (T1D) who took bromocriptine, a medication used to treat Parkinson's disease and Type 2 diabetes, had lower blood pressure and less stiff arteries after one month of treatment compared to those who did not take the medicine. People with T1D have a higher risk of developing heart disease. "We know that abnormalities in the large vessels around the heart, the aorta and its primary branches, begin to develop in early childhood in people with Type 1 diabetes," said Michal Schäfer, Ph.D. "We found that bromocriptine has the potential to slow down the development of those...

Dapagliflozin reduces risk for hospitalization in patients with CKD with or without diabetes (Death Risk Ratio of .79 w/Farxiga)
12/06/2022 4:58:25 PM PST · by ConservativeMind · 2 replies
Medical Xpress / American College of Physicians / Annals of Internal Medicine ^ | Dec. 6, 2022 | Meir Schechter et al
Dapagliflozin, a sodium-glucose cotransporter-2 (SGLT2) inhibitor, reduced the risk for hospitalization for any cause in patients with chronic kidney disease (CKD) with and without type 2 diabetes. The findings suggest that dapagliflozin should be considered in such patients. Patients with CKD are often hospitalized, contributing to lower quality of life and higher health care costs. Prior studies have shown that SGLT2 inhibitors can reduce cardiovascular events and slow progression to kidney damage in patients with or without diabetes. The effect of these drugs on hospitalizations in patients with CKD is less clear. Researchers from University of Groningen, Groningen, the Netherlands...

Surprise leading causes of excess hospitalization for people with type 2 diabetes (Iron deficiency, mental and gastrointestinal issues)
11/24/2022 8:03:10 PM PST · by ConservativeMind · 7 replies
Medical Xpress / Baker Heart and Diabetes Institute / Diabetes Research and Clinical Practice ^ | Nov. 23, 2022 | Catherine Butterfield / Dunya Tomic et al
Findings reveal that some unexpected conditions are leading to more hospitalizations in people living with type 2 diabetes compared to the general population. The emergence of iron deficiency anemia, mental health disorders and gastrointestinal disorders as leading reasons for excess hospitalization among those with type 2 diabetes compared to the general population was met with some surprise by Professor Dianna Magliano. The study found that people with type 2 diabetes are far more likely to be hospitalized with iron deficiency anemia than those without diabetes. "Our findings suggest the possibility of a biological link between type 2 diabetes and iron...

Study finds that diabetes may hasten breast cancer tumor growth and stiffness
11/22/2022 1:12:47 PM PST · by ConservativeMind · 3 replies
Medical Xpress / Vanderbilt University / Science Advances ^ | Nov. 21, 2022 | Wenjun Wang et al
While diabetes is already associated with an increased risk of developing breast cancer, a new study indicates that presence of the disease may increase tumor growth and stiffness. Researchers also found that diabetes treatments could reduce the tumor growth and stiffness to levels comparable with non-diabetic ones. The study sheds light on a previously unknown biomechanical mechanism in which diabetic hyperglycemia acts on the extracellular matrix—a molecular network that promotes the growth of cells—to accelerate tumor growth and stiffness in breast cancer. The research offers potential evidence for future therapies targeted to diabetic cancer patients.

High-fat diet can provoke pain sensitivity without obesity or diabetes (Palmitic fatty acid)
11/14/2022 9:24:15 PM PST · by ConservativeMind · 7 replies
Medical Xpress / University of Texas at Dallas / Scientific Reports / ^ | Nov. 14, 2022 | Jessica A. Tierney et al
A study in mice suggests that a short-term exposure to a high-fat diet may be linked to pain sensations even in the absence of a prior injury or a pre-existing condition like obesity or diabetes. The study compared the effects of eight weeks of different diets on two cohorts of mice. One group received normal chow, while the other was fed a high-fat diet in a way that did not precipitate the development of obesity or high blood sugar, both of which are conditions that can result in diabetic neuropathy and other types of pain. The researchers found that the...

Cholesterol and diabetes drugs may lessen risk of degenerative eye disease associated with aging
11/08/2022 1:52:46 PM PST · by ConservativeMind · 9 replies
Medical Xpress / British Medical Journal / British Journal of Ophthalmology ^ | Nov. 7, 2022 | Matthias M Mauschitz et al
Regular use of drugs to lower cholesterol and control type 2 diabetes may lessen the risk of the degenerative eye disease associated with aging, known as AMD, finds a pooled data analysis. AMD is the leading cause of severe visual impairment among older people in high-income countries. AMD affects central vision and the ability to see fine detail. Various genetic and environmental factors associated with aging are thought to trigger AMD, but it's still not clear how best to prevent it or slow its progression. Previously published research suggests that drugs to lower cholesterol, control diabetes, and tamp down inflammation...

At risk for diabetes? Cut the carbs, says new study
10/27/2022 8:57:00 AM PDT · by ConservativeMind · 35 replies
Medical Xpress / Tulane University / JAMA Network Open ^ | Oct. 26, 2022 | Kirsten Dorans et al
While low-carb diets are often recommended for those being treated for diabetes, little evidence exists on whether eating fewer carbs can impact the blood sugar of those with diabetes or prediabetes who aren't treated by medications. According to new research, a low-carb diet can help those with unmedicated diabetes—and those at risk for diabetes—lower their blood sugar. The study compared two groups: one assigned a low-carb diet and another that continued with their usual diet. After six months, the low-carb diet group had greater drops in hemoglobin A1c, a marker for blood sugar levels, when compared with the group who...

Researchers identify diabetes drug metformin as potential atrial fibrillation treatment in collaborative research
10/11/2022 8:12:08 PM PDT · by ConservativeMind · 14 replies
Medical Xpress / Cleveland Clinic / Cell Reports Medicine ^ | Oct. 11, 2022 | Jessica C. Lal et al
researchers have identified a common diabetes medication, metformin, as a possible treatment for atrial fibrillation. The study built on ongoing research to support metformin as a drug repurposing candidate. Researchers used advanced computation and genetic sequencing to determine that metformin's targets overlap significantly with genes dysregulated in atrial fibrillation. "Finding drugs or procedures to treat atrial fibrillation is difficult because of potential serious side effects," said Mina Chung, M.D. "There is a significant need for new treatments for atrial fibrillation as there have been no new drugs approved in more than a decade." "It's not that we've found a new...

Type 2 diabetes remission is possible even in people with lower body weight, supporting idea of 'personal fat threshold'
09/24/2022 1:02:19 PM PDT · by ConservativeMind · 34 replies
Medical Xpress / Diabetologia / European Association for the Study of Diabetes (EASD) ^ | Sept. 22, 2022 | Professor Roy Taylor et al
Everyone has a "personal fat threshold," which if exceeded, will allow type 2 diabetes (T2D) to develop, even if they are of a lower body weight. The ReTUNE Study looked at whether weight loss can also reverse the condition in people with a BMI at or only just above the "normal" range (BMI below 27kg/m2). Men and women with T2D followed a weight loss program in which they consumed 800 calories a day for two weeks, followed by four to six weeks in which they kept their new weight steady. They completed up to three rounds, until they had lost...

Protein restriction can be effective in combating obesity and diabetes, study suggests
09/23/2022 3:19:21 PM PDT · by ConservativeMind · 31 replies
Medical Xpress / FAPESP / Nutrients ^ | Sept. 20, 2022 | Maria Fernanda Ziegler / Rafael Ferraz-Bannitz et al
Cutting protein intake can help control metabolic syndrome and some of its main symptoms, such as obesity, diabetes and high blood pressure (hypertension), according to a study. "The study showed that cutting protein intake to 0.8 g per kg of body weight was sufficient to achieve almost the same clinical results as restricting calories, but without the need to reduce calorie intake. The results suggest that protein restriction may be one of the key factors leading to the known benefits of dietary restriction. Protein restriction dieting may therefore be a more attractive nutritional strategy and easier to follow for people...

'Night owls' could have greater risk of type 2 diabetes and heart disease than those who are 'early birds'
09/23/2022 3:02:20 PM PDT · by ConservativeMind · 16 replies
Medical Xpress / The Physiological Society / Experimental Physiology ^ | Sept. 20, 2022 | Professor Steven Malin et al
Are you an early bird or a night owl? Our activity patterns and sleep cycles could influence our risk of diseases, such as type 2 diabetes and heart disease. New research has found that wake/sleep cycles cause metabolic differences and alter our body's preference for energy sources. The researchers found that those who stay up later have a reduced ability to use fat for energy, meaning fats may build up in the body and increase risk for type 2 diabetes and cardiovascular disease. The metabolic differences relate to how well each group can use insulin to promote glucose uptake by...

Two popular diabetes drugs outperform others in large clinical trial (Insulin glargine and liraglutide)
09/22/2022 9:17:15 PM PDT · by ConservativeMind · 9 replies
Medical Xpress / National Institute of Diabetes and Digestive and Kidney Diseases / NEJM ^ | Sept. 21, 2022 | Dr. Henry Burch et al
In a large clinical trial that directly compared four drugs commonly used to treat type 2 diabetes, researchers found that insulin glargine and liraglutide performed the best of four medications to maintain blood glucose levels. While there is general agreement among health care professionals that metformin combined with diet and exercise is the best early approach in diabetes care, there is no consensus on what to do next to best keep high blood glucose in check. The study enrolled 5,047 people with type 2 diabetes who were already taking metformin. Three groups took metformin plus a medicine that increased insulin...

Cold exposure could help combat type 2 diabetes, particularly if it provokes shivering
09/22/2022 8:26:23 PM PDT · by ConservativeMind · 16 replies
Medical Xpress / Diabetologia / European Association for the Study of Diabetes (EASD) Annual Meeting ^ | Sept. 21, 2022 | Adam Sellers, Sten van Beek et al
Research finds that shivering during repeated exposure to cold improves glucose tolerance, decreases fasting blood sugar and blood fat levels, and markedly reduces blood pressure in overweight and obese adults. The preliminary study highlights the potential for repeated cold exposure that activates shivering as an alternative strategy to treat and prevent type 2 diabetes (T2D). "When we are cold, we can activate our brown fat because it burns energy and releases heat to protect us. In addition, muscle can contract mechanically, or shivers, thereby generating heat. As there is considerably more muscle than brown fat in a human, shivering can...

Study finds increased risk of type 2 diabetes after hysterectomy especially in younger women
09/22/2022 3:10:32 PM PDT · by ConservativeMind · 3 replies
Medical Xpress / Diabetologia / European Association for the Study of Diabetes (EASD) Annual Meeting ^ | Sept. 21, 2022 | Professor Fabrice Bonnet et al
Women (especially those aged younger than 45 years) who have undergone a hysterectomy may be at greater risk of developing type 2 diabetes (T2D), according to a study of more than 83,000 middle-aged French women who were followed for an average of 16 years. "The findings suggest that women who undergo hysterectomy before the age of 45 have a 52% increased risk of developing incident type 2 diabetes," says Professor Fabrice Bonnet. Hysterectomy may be recommended as a treatment for heavy periods, fibroids, endometriosis, and gynecological cancers. The surgery removes the uterus (or womb), sometimes along with the fallopian tubes,...

Diabetes and oral diseases affect each other and hinder treatment
09/22/2022 2:56:18 PM PDT · by ConservativeMind · 8 replies
Medical Xpress / University of Helsinki / Frontiers in Oral Health ^ | Sept. 21, 2022 | Pia Heikkilä et al
Research shows that common chronic diseases and problems associated with oral health have a detrimental and long-term reciprocal effect on each other. The predictive value of oral health for the onset of various chronic diseases was investigated through a 10-year follow-up. A key finding was that periodontitis (a disease of the connective tissue of teeth) has a particular link with diabetes. "We know from prior studies that periodontitis has a connection to many chronic diseases. Thanks to our exceptionally long-term dataset, we were able to analyze causalities and bidirectional effects between these factors," says Pia Heikkilä. The results of the...

Liver protein protects against stiff arteries in obesity and diabetes (Adropin increasable by diet and weight loss)
09/21/2022 8:18:56 AM PDT · by ConservativeMind · 9 replies
Medical Xpress / American Journal of Physiology-Heart and Circulatory Physiology ^ | Sept. 20, 2022 | Thomas J. Jurrissen et al
New research identifies the importance of the protein adropin in preventing stiffness in the arteries of people with obesity and type 2 diabetes. Arterial stiffness is a condition associated with aging and insulin resistance, a chronic condition associated with obesity, and is a major contributor in the development of cardiovascular disease, including heart attack and stroke. Adropin, a protein produced by the liver and other tissues, is involved in maintaining energy balance in the body and the metabolism of fat and sugar. Previous studies have suggested that adropin also plays a role in regulating cardiovascular health. People with chronic conditions...

A healthy lifestyle almost halves the risk of dementia in people with type 2 diabetes
09/19/2022 7:57:38 PM PDT · by ConservativeMind · 17 replies
Medical Xpress / Diabetologia / European Association for the Study of Diabetes (EASD) ^ | Sept. 19, 2022 | Ms. Jirapitcha Boonpor and Dr. Carlos Celis-Morales et al
A healthy lifestyle reduces the risk of dementia in those with type 2 diabetes (T2D), according to a study. The study found that individuals with T2D and an unhealthy lifestyle were much more likely to develop dementia than people without T2D and a very healthy lifestyle. However, a healthy lifestyle almost halved the likelihood of people with T2D developing dementia. An unhealthy lifestyle and T2D are known to individually raise the risk of dementia. It hasn't, been clear, however, whether a healthy lifestyle can reduce the risk of dementia in those with T2D. The 445,364 participants (54.6% female) had an...

Plus-size Philadelphia drag queen, 25, DIES during performance at gay bar: Medical examiner says she was killed by heart disease, obesity and diabetes
09/17/2022 10:07:53 AM PDT · by algore · 56 replies
daily mail ^
Tributes have been paid to a ‘bright and rising’ plus-size drag queen who collapsed and died mid-performance at a Philadelphia bar aged just 25. Valencia Prime had been in the middle of her ‘Prime Time’ show at the Tabu Lounge and Sports Bar on September 12 when she crumpled on-stage. Prime, who called herself ‘Philadelphia’s Plus Size Dancing Diva’, died as a result of heart disease, obesity and diabetes according to the medical examiner – with her cause of death being ruled as natural causes. Paramedics and emergency services were called to the gay bar as the transgender drag queen...

Dairy products in moderate amounts may protect against type 2 diabetes: Red and processed meat may raise risk
09/16/2022 8:00:28 AM PDT · by ConservativeMind · 24 replies
Medical Xpress / Diabetologia / Annual mtg. of the Eur. Assoc. for the Study of Diabetes ^ | Sept. 15, 2022 | Dr. Annalisa Giosuè et al
Research shows that dairy products, especially low-fat products and yogurt, are associated with a lower risk of developing type 2 diabetes (T2D). Red and processed meat were linked to a higher risk of T2D but moderate amounts of fish and eggs could be eaten in their place, say the Italian researchers. Dr. Annalisa Giosuè and colleagues carried out a review of existing meta-analyses into links between different animal-based foods and diabetes. This type of "review of reviews" provides one of the highest levels of evidence available in medicine. There was a substantial increase in T2D risk with the consumption of...

Long-term study determines recommended blood sugar levels to avoid diabetes-related damage (HbA1c < 53 mmol/mol (7%))
09/13/2022 8:14:39 PM PDT · by ConservativeMind · 33 replies
Medical Xpress / Linköping University / Diabetes Care ^ | Sept. 12, 2022 | Hans J. Arnqvist et al
The levels of long-term blood sugar, HbA1c, can be used to accurately determine the risk of a person with type 1 diabetes developing eye- and kidney complications. A study has shown that this level should be lower than 53 mmol/mol (7%). The study has followed individuals for more than 30 years after the onset of type 1 diabetes. People with diabetes may experience damage to the small blood vessels in various organs. The reasons for this are unclear, but it has been known that good control of blood sugar levels reduces the risk of complications. It has, however, not been...
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