The 17s had a service altitude of around 35,000 feet - about the same cruise altitude as a modern airliner, but without the pressure body. Most missions were flown between 20,000 and 30,000 feet - from 3.7 to about 5.6 miles up - unpressurized. Go read Flying Fortress by Jablonski, and look how far away the ground is on those low altitude missions.
Even if they caused a sudden depressurization that would be no big deal.
No big deal to who?