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Another question is what's happened in the general election when they've knocked off the incumbent?

I don't know the answer to that, but I do know they are an invaluable asset in close race open seats. I think they view their mission in GOP primaries to at least rough up a RINO incumbent. That's usually easier to do to a House member given they run every 2 years. With 6 year terms a Senator can raise more money and make a much more difficult target. They certainly help in open seat general elections. But with a what, 95-98% relection rate in general elections, its always an uphill battle.

The Club for Growth has been itching for a RINO scalp and I think they will get one tomorrow. I believe Bush will pressure Specter to endorse and campaign for Toomey and will probably offer him a position in the second administration if he plays along. I think Bush has a better chance of winning PA with Tommey on the ticket.

Considering the number of open seats and the huge financial advantage the GOP has I think we're in line for a 4 seat pickup. If Kerry continues to be such a poor candidate this may move up to 6 seats.