Isabella was a close relative of Rene (and most of the other royals, who were, of course, close relatives to each other).
Rene's biggest source of cash income was the wool trade. He shipped wool from Iceland to Turkey where it was made into rugs. Rene was also a Cardinal although he is credited with having had 2 wives and 3 concubines (all of noble lineage ~ kings, that sort of thing).
My bet's on Rene and Christopher having a "close" kinship ~ they were both redheads too, and that other guy, the Pope, who has a remarkable resemblance to Columbus ~ well, there were a variety of ways that could have come about!
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