If any 747s manage to enter US airspace without proper clearance they won't get very far. You could get a light aircraft in, but you can do more damage with a moving van full of fertilizer.
A much bigger risk is a dirty bomb in a shipping container set to explode in the middle of a major US port.
This would be bad, but I would think it would be much easier to do substantial damage by carjacking a bunch of gasoline tankers and going after bridges, tunnels, and even ramming large buildings.