Generally speaking, not much offends me, especially if it's comedy or sarcastic humor.
I really enjoy South Park, and it's commentary on today's society.
But for the life of me, I still can't find anything funny about "Mr. Hanky".
The Mr. Hanky joke is that almost anything can, via media manipulation and sympathetic portrayal can be made "cute" and loveable. Think PETA telling us that even insects are sympathetic creatures that we should feel a loving caring bond with. Mr. Hanky is of course revolting to everyone except for that small percentage of the population who can be manipulated into feeling sympathy towards anything. For instance, I have seen people wearing Mr. Hanky t-shirts. They obviously didn't get the joke.