Nice find, Wolfie! By UKCajun's logic, this proves that cigarettes cause mental illness.
AB: Discusses how the psychoactive ingredient in marijuana, Delta9-tetrahydrocannabinol (THC), interferes with short-term memory in both delayed match and delayed nonmatch to sample tasks (DNMS). Animal studies have shown that other cannabinoids, such as the potent cannabinoid receptor (CB1) agonist, WIN 55,212-2 produces a delay-dependent deficit in the DNMS task at a dose range well below that of Delta-sup-9-THC, which was blocked by the CB1 receptor antagonist SR141716A. The effects of WIN 55,212-2 at low doses were similar to those of isolated lesions of the hippocampus, whereas high doses (0.50 mg/kg) produced effects similar to lesions of both hippocampus and surrounding retrohippocampal areas. The low dose effect was delay-dependent while the high dose introduced an additional deficit at short delays that was sensitive to SR141716A and phaclofen. Comparison of lesion vs cannabinoid effects on DNMS performance suggests that CB1 receptors on hippocampal neurons interfere with the processing of DNMS task-specific information within a trial. CB1 receptors on hippocampal gamma-aminobutyric acid (GABA)ergic interneurons and in retrohippocampal areas appear to influence the ability to maintain segregation of information between trials in the task.
(PsycINFO Database
Record (c) 2000 APA, all rights reserved)
AU: Hampson,-Robert-E; Deadwyler,-Sam-A
AF: Wake Forest U, School of Medicine, Dept of Physiology and Pharmacology, Winston-Salem, NC, US
SO: Life-Sciences. 1999 Jul; Vol 65(6-7): 715-723.
JN: Life-Sciences;
PB: US: Elsevier Science, Inc.
IS: 0024-3205
PY: 1999
URLP: www.elsevier.com
LA: English
KP: role of delta-9-THC and cannabinoid receptors in hippocampus in short-term memory interference MJ: *Cannabinoids-; *Hippocampus-; *Neural-Receptors; *Short-Term-Memory; * Tetrahydrocannabinol- MN: Cognitive-Ability; Neurobiology- CC: 2580-Psychopharmacology; 2580; 25 SF: References UD: 19991101