A smart GOP would attack the 'RATs in the South as the Party of the North. They are bigoted and prejudiced against Southerners. They want to run everyone's life. Etc.
They are not prejudiced against just Southerners. Liberals are also prejudiced against Northerners, and I don't think you can properly label the bigots who live in Palm Beach as being all that "Northern".
Then there are the Middle-States bigots like Mikulski. If post-generational reverse deportation were lawful, she'd be the one I'd wish to be first in line.