Without degradation? With complete compatibility in full resolution?
Yes, though that would void the warranty.
As I would with any PC mod I make...
Complete compatability in full resolution? Yes. That's what VPC does. Degradation? In what manner? Speed? Speed will take a hit commeasurate with the version of VPC you are using (the newer versions are, understandably, better), but may or may not be a factor, depending on the game. For example, I'd just be toast with Unreal Tournament in emulation, but Links 2001? What? I wouldn't sail into the rough as quickly?