It’s not unfamiliar at this point.
The pronunciation is unfamiliar. The most well known Kamala in America, prior to Harris, was a wrestler named Kamala. His name was pronounced Ka-MAL-a. Few Americans ever dealt with the name until Harris came on the scene four years ago. The media tried to make a big issue out of it four years ago, but she wasn’t important enough for people to change their pronunciation to the more awkward KA-mal-a.
In the past 4 years, many in the media have continued to pronounce it Ka-MAL-a, so the average person is as likely to unintentionally mis-pronounce her name as they are to pronounce it correctly because it’s what they’ve heard.