Refuse to wear it, let them, make you wear it.
They will literally duct tape you to your seat, land the plane somewhere and drag you off the plane to awaiting federal marshalls.
Civil disobedience works but only if it's in large numbers or it has the support of the media to make it a cause celeb like that guy in Tiananmen Square. Otherwise they just disappear you to a prison somewhere.
The Flight attendants will call the Police on you. I was on a flight from DC to Chicago 2 weeks ago - the nasty Flight attendant threatened the guy in front of me if refused to wear his mask. He finally put it on.