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Modified RNA has a direct effect on DNA ^ | JANUARY 29, 2020 | by Eyrun Thune, University of Oslo

Posted on 02/17/2021 1:02:43 PM PST by RomanSoldier19

An article titled "m6A RNA modification as a new player in R-loop regulation," by the Dynamic Gene Regulation research group led by Arne Klungland at IMB, was published in the January edition of Nature Genetics.

Following a new collaboration between UiO and research groups in Nottingham and Oxford, it has now been revealed that RNA has a direct effect on DNA stability, according to Professor Klungland's research.

He believes the discovery will provide the health service with an important tool, since many studies have shown that the regulation of modifications to RNA is important for the development of cancer.

If genes that are important for the chemical compound 6-methyladenine are completely removed, this results in neurodegeneration in both mice and humans.

(Excerpt) Read more at ...

TOPICS: News/Current Events
KEYWORDS: bvitamins; cancer; cancerresearch; epigenetics; genetics; ivermection; mrna; rna; vaccine
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To: DugwayDuke
Just look at some of the comments on this very thread.

Willfully ignorant individuals.

Things like polio would still be running rampant if the vaccines for those were released in the present day.

41 posted on 02/17/2021 4:50:29 PM PST by Republican Wildcat
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To: gas_dr
Ping - here we go again.

Completely different subject being related to an mRNA vaccine.

Probably not as good as the person who argued mRNA was mitochondrial, but it's close.

42 posted on 02/17/2021 4:52:57 PM PST by Republican Wildcat
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To: moovova

“I like to date school teachers. If you do something wrong, they make you do it over again.” - Dangerfield

43 posted on 02/17/2021 4:56:48 PM PST by DannyTN
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To: saintgermaine

It’s one thing to develop a vaccine on the quick. I understand why that would be necessary (though in the case of COVID-19 I don’t believe it is), but to use a novel technology like mRNA for the first time - no thank you.

Especially if there are other efficacious methods of dealing with it.

44 posted on 02/17/2021 5:00:17 PM PST by RinaseaofDs
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To: Rocco DiPippo

This is all relatively new and I’m learning like everyone else. But here is a quick summary of my limited understanding.

In the past vaccines were either a dead virus or a similar virus that had limited effect on humans. These were injected into the body where our immune system attacked them and destroyed infected cells.

Lymphocytes are white blood cells that are immune cells that attack the virus. B lymphocytes are made in the bone marrow and found in the blood and lymph tissue. T cell lymphocytes are made in the thymus.

The dead virus particles, called antigens are pathogens that are attacked by the lymphocytes to cleanse the body. T cells, also called T helper cells, produce cytokines that direct the immune response. (Many of the deaths are blamed on a “Cytokine Storm,” a great immune system response that was creating the lung congestion leading to respiration stoppage.)

The B lymphocytes are memory cells that create the long term immunity as they hang around and as soon as similar antigens are identified, it triggers a fast immune response. The purpose of the vaccine is to produce these B memory lymphocytes for rapid immune response, protecting against the virus from rapid replication in the future.

The new “vaccine” does not use dead or weakened virus to trigger the immune system. It uses genetically engineered antigens which replicate genetic fingerprints of the dead virus particles.

The concern is that when you genetically engineer a virus particle that triggers an immune response, what are the end results. It is a key that unlocks the immune system. What other tissue or cells in the body will be attacked when the genetically engineered antigens (the new vaccines) acts as a key to create immune response.

We have already heard several cases where the vaccine potentially triggerd an autoimmune response that destroyed platelets in the blood, thus decreasing its ability to clot. This is wat killed the Dr. in Orlando and is blamed for killing several fetuses in pregnant women receiving the new vaccine.

Could it trigger something similar to MS, or Lupus, or Vasculitis, or Myocarditis, or ALS,...... in the future? No one knows.

One concern I have is that when you start genetically engineering antigens, could these be race or gender, or ethnic origin specific? Could you develop an antigen that triggers an immune response causing sterilization or infertility?

There are more unanswered questions than there are answers at this time.

The PCR tests are used to directly detect the presence of an antigen, the genetic information of the virus or RNA sequence rather than the presence of the body’s immune response, or antibodies. Thus some people who had the vaccine are testing perpetually positive for the virus.

I personally am waiting for the J&J vaccine that is dead virus cells, even though it is possibly not as effective. My only reason for getting it is I expect it to be a requirement for international travel in the future and I travel frequently.

If there are important parts missing to my explanation or if my understanding is incorrect, please feel free to make necessary additions/corrections. This is a very simplified explanation.

45 posted on 02/17/2021 5:01:18 PM PST by tired&retired (Blessings )
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To: Republican Wildcat

What they are talking about is the transcription process which as you lint out has nothing to do with the vaccines. Actually this is quite exciting as a targeted cancer treatment but what most of the molecular biology illiterates will not understand is that the messenger RNA vaccines currently are in the transcribed form and merely seeking translation to create the protein for immunity.

What we have is the equivalent of the liberals who see Trump and with Pavlovian accuracy say orange man bad. When some of our friends see rna they have a Pavlovian reaction of evil vaccine bill gates generic modification without any rational experience or thought. But ring a bell and you can make anything drool.

46 posted on 02/17/2021 5:06:20 PM PST by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: EEGator

I know this sounds bizarre, but I feel the consciousness of the virus as separate from the consciousness of the individual. The best description I have is that it feels as though I am reaching into a swarm of gnats.

I had the Covid virus really bad as I attended the packed Chinese New Year celebration in Chinatown Bangkok, Thailand last January 25/26th. Bangkok is warm while China is cold, thus everyone flocks to the warm south for holiday just as the New Englanders head to warm Florida. This was prior to us knowing much about the virus.

Three days later, I was in Chang Mai, Northern Thailand with severe symptoms, constant dry cough, fatigue, fever, stomach and muscle cramps. I sat in the hotel, too sick to visit the temples I had planned. Two things happened. First I was headed for a several day boat trip down the Mekong River in Laos and I started taking hydroxychloroquine as a prophylactic for malaria. This was before we knew it worked.

The second thing amazed me and my wife who watched me do this. Her eyes were like saucers she couldn’t believe what happened. I was doubling over with these constant coughing spells. I reached in front of my chest and took hold of the virus and pulled it out of me. The coughing stopped immediately and did not return. The chest cleared, my respiration returned to normal in minutes, to the point where I headed out hiking the trails to the mountain top Buddhist temples. I’ll admit, I too was shocked. I would not expect anyone to believe this as I saw and experienced it myself and still have a hard time believing it.

47 posted on 02/17/2021 5:19:31 PM PST by tired&retired (Blessings )
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To: tired&retired

Its not a bad high level look, but the point that needs more refining is that the mRNA does not create genetically engineered antigens. Corona Virus is an RNA virus (SS RNA to be precise, there are some really weird DS RNA but thats another story). Once the virus sheds its capsule after gaining entry into the cell (with CoVID it is the spike protein that allows penetration of the cell membrane which is a lipid bilayer) it exposes its RNA to the ribosomes and starts to translate its protein. because the RNA is the entire virus, it replicates proteins for more whole virus.

So the current vaccine has the mRNA of the spike protein only. It is exactly what the virus does...but in this case the only thing coded for is the spike protein. Once the spike protein is replicated, the immune system says essentially “what the hell is that” and mounts the initial immune response (IgM antibodies). Once this occurs the second poster exposes the immune system and there is a larger response but this is the key to driving T-cell immunity which is memory immunity.

So “traditional” vaccines inject either the isolated protein for which to generate an immune response, or a live attenuated virus that hopefully does not cause a true infection. So in effect, the mRNA technology acts just like the virus, but does not create an entire and virulent copy, rather creates immunity in a much safer way.

This technology will lead to targeted Cancer and Viral vaccine in the future. It is a true breakthrough.

48 posted on 02/17/2021 5:24:32 PM PST by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: Republican Wildcat

The hysterical mrna vaccine bad crowd do not want the truth. At some point you are casting pearls before swine.

49 posted on 02/17/2021 5:28:02 PM PST by Mom MD
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To: gas_dr

“This technology will lead to targeted Cancer and Viral vaccine in the future. It is a true breakthrough.”

I sure hope so. Thanks for adding the important information. Viruses are not my forte’. I spent some time in the virus textbook last December (2019) as I was getting a lot of vaccines for foreign travel, and wanted to understand them. Spent some time learning the Baltimore classification system and the various categories of viruses. I’m getting older and the memory doesn’t work like it used to!!!

50 posted on 02/17/2021 5:33:05 PM PST by tired&retired (Blessings )
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To: gas_dr

There is one part of your commentary that I would like to clarify. I agree with you, but I focused on how the genetic sequence of the virus spike protein was made, i.e. the vaccine that is injected into the body.

You stated, “they teach our cells how to make a protein—or even just a piece of a protein—that triggers an immune response inside our bodies.” That is correct. But the “teaching” is done by injecting an artificially generated RNA sequence or segment that replicates the spike protein of the virus.

What makes this different is that the segment is artificially created and not a part of a virus. Is the imitation identical? Hope so.

51 posted on 02/17/2021 5:41:11 PM PST by tired&retired (Blessings )
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To: gas_dr

Two of my children went into genetic engineering and cloning research in med school, my daughter’s research related to malaria virus and Babesia. For me, it’s like computers, when you want to understand something, ask your children!!!

52 posted on 02/17/2021 5:47:36 PM PST by tired&retired (Blessings )
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To: gas_dr

My apologies... I now understand.

They are creating the mRNA sequence that is used by the ribosomes to create the spike protein that is the antigen. You are correct, they are not directly creating the antigen, but are indirectly creating it by creating the recipe in the mRNA.

Thank you for challenging me. I am always willing to learn.

53 posted on 02/17/2021 5:55:52 PM PST by tired&retired (Blessings )
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To: tired&retired

Thats a really great question.

Because the entire genome of Corona - 19 has been mapped, it is easy to map the gene for the spike protein. The mRNA is thus synthesized for just that gene, so you only translate the spike protein.

It really is rather elegant. It is an arrow right at the Achilles heel of the virus. Because it is only this sequence that is exposed to the ribosomes, only this protein is made.

54 posted on 02/17/2021 5:57:46 PM PST by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: tired&retired

You beat me to it by 8 seconds... and you are correct. This actually is elegant because it works just like the virus, except you dont get infected, just immunity.

55 posted on 02/17/2021 5:59:01 PM PST by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: gas_dr

I am familiar with the injection of anti-vascular endothelial growth factor (VEGF) for controlling wet macular degeneration(injected into the eye to stop vascular genesis), and knew that they were using anti-VEGF to control cancer growth.

I just read an article on how they are using mRNA for VEGF in cancer research. Wow, my head is spinning at the possibilities.

My son recently turned down a job in research using a person’s cells and tissue in a device that is basically a 3-D printer, printing body parts, organs, cartilage and skin to graft onto/into people as replacement body parts that are not rejected by their immune system. Amazing how much medicine has changed in the last ten years.

56 posted on 02/17/2021 6:10:57 PM PST by tired&retired (Blessings )
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To: gas_dr

Doc, Thank you for all the useful info you post on the vaccines. May I ask if you have a preference among the vaccines? Thank you.

57 posted on 02/17/2021 6:20:33 PM PST by Sloopy
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To: Sloopy

Sure, I had the Pfizer vaccine because it was the first available to front line physicians like me. So It was a matter of timing.

I think that there is no particular distinction between the Pfizer and the Moderna. The moderna seems to have stronger second injection side effects. I had a mild fever and about 6 hours of aches and pains with my second Pfizer.

I think that for people who are recalcitrant that the single J&J is probably an excellent choice. Although there is still a 30% chance of infection, there is no progression to severe disease -> a good compromise.

But in direct response, I prefer the Pfizer.

58 posted on 02/17/2021 6:31:31 PM PST by gas_dr (Trial lawyers AND POLITICIANS are Endangering Every Patient in America: INCLUDING THEIR LIBERTIES)
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To: gas_dr

Thanks, Doc. (Hope you don’t mind being called Doc).
I appreciate the info.

59 posted on 02/17/2021 6:52:08 PM PST by Sloopy
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To: House Atreides

Actually, it does. Dr Carrie Madej also refers to the CV19 shots as “modified messenger RNA” in her videos. She isn’t arrogant either. Oh and look! right in Wikipedia, by DEFINITION: modRNA is synthetic mRNA, like CV19 gene therapy ‘vaccines’

“Nucleoside-modified messenger RNA

A nucleoside-modified messenger RNA (modRNA) is a synthetic messenger RNA (mRNA) in which some nucleosides are replaced by other naturally modified nucleosides or by synthetic nucleoside analogues. modRNA is used to induce the production of a desired protein in certain cells. An important application is the development of mRNA vaccines, of which the first authorized were COVID-19 vaccines (such as BNT162b2 and mRNA-1273). ...”

60 posted on 02/17/2021 6:56:47 PM PST by guthunde47
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