Since my Harvard lab closed yesterday, I've been reading and interpreting this week's published papers on #COVID19. What follows is a thread of information, my interpretation, links to sources & predictions. Let's start with what you need to know... #coronavirus #COVIDー19
Treatments that seem to work are chloroquine (a cheap malarial drug), Gilliad's remdesivir with interferon-beta (in clinical trials from COV-19), plasma from recovered patients, and a steroid (methylprednisilone). Doctors in US are now using remdesivir off-label...
SARS-CoV2 attacks pneumocytes in lung, intestine, heart & cells lining blood vessels. In lung, CoV2 prevents cells from making biological detergents to keep lung passages open. Acute respiratory distress follows. O2 levels fall..but there's may be a dangerous underlying process.. ..new work out of China yesterday says COVID-19 might also involve abnormal blood production. CoV genes 1 & 8 are predicted to interfere with heme, the red compound in blood, by kicking out the iron. Would explain why chloroquine seems effective as a treatment #CoronaVirusUpdate
Chloroquine is predicted to prevent orf1ab, ORF3a and ORF10 from attacking heme (red in red blood cells) and inhibit the binding of ORF8 to heme. Although 99% of the virus is seemingly stable, what's disturbing is ORF 1 and 8 are mutating the fastest...
..Positions nt28144 in ORF 8 and nt8782 in ORF1 are evolving. Samples out of China show they'd mutated 30.53% (29/95) and 29.47% (28/95), respectively. I'm currently figuring out why these are the ones mutating and how that would change the situation...
It may explain why diabetics and elderly are more susceptible. Blood sugar levels usually increase as we get older, increasing the amount of glycated hemoglobin (HbA1c) (I've tweeted about this before). The authors suggest these people would be more susceptible to because... ...the virus could more easily disrupt the heme in red blood cells. If so, the virus is very smart: it destroys the lung so patients can't take up oxygen AND reduces the body's ability to carry oxygen. (For this & other reasons, you should eat healthily the next 2 years)...
These ideas are testable. COVID-19 should correlate with HbA1c levels (seems true). Patients should have abnormalities in heme/porphyrin & they might have higher levels of free iron in tissues & blood. I will update with more info as it comes in. Stay safe. Below are links... Blood, HbA1c, and chloroquine COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin COVID-19 Disease: ORF8 and Surface Glycoprotein Inhibit Heme Metabolism by Binding to Porphyrin https://tinyurl.com/w28et45
CoV2 mutations tinyurl.com/secncmf Symptoms tinyurl.com/ubncbgn Susceptibility/Risk tinyurl.com/vexo5vl Fatality tinyurl.com/sb8qpza Therapies tinyurl.com/vrm7f5j Remdesivir
Wow, my blood type is AB positive which makes me a near “universal” plasma donor. The could order me and others with AB positive blood type back to active duty, infect us with Wuhan Coronavirus and, once (if) we recovered, make us regular plasma donors. Hell, we’d solve the whole damn problem ... or at least mitigate it.
Tonic water and zinc
South Korea was having success with the malaria drug and zinc
Interesting. Thanks for posting.
Just had my A1C done: 6.9
Good timing on my part.
CC
Bkmrk
I keep getting a feeling this is man made. a malaria cocktail to resolve a cold air flu virus.
” (For this & other reasons, you should eat healthily the next 2 years).”
Meaning what?
Someone with a "Harvard lab" ought to know what "off-label use" means.
mark
Hydroxychloroquine is more effective, safer, and more widely available for use as a zinc ionophore. OTC quercetin is also a zinc ionophore but the dosage is unknown.
From someone who tracks and admires David Sinclair, thank you for posting this! There is a world of good information in his article. I recently purchased his book, Lifespan, Why We Age and Don’t Have To. http://bit.ly/2r0silo. I have followed his lifestyle prescription for many years. I only recently discovered it has been scientifically proven when I discovered his book. If you are interested, here is a YouTube video where he discusses his theory — http://bit.ly/2OVFvEb.
This has sure worked for me and apparently from his discussion for the mice, too :-).
IC Clearly