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Ms. Sprecht is the Associate Director of Science & Technology @GoodFoodInst. Supporting alternative proteins for a sustainable food future. UCSD PhD Biology, Johns Hopkins University ChemBE.
Ms. Sprecht is right that people do not understand exponential growth. This is truly frightening information. She's right about the exponential growth phase of a pandemic - if you think an estimate is too high, just wait a few days or a week. She concentrates on the shortage of general hospital beds and masks. But the big problem is that we will run out of isolation rooms very quickly and mechanical ventilators not long after that.
Let’s trust Italy’s numbers and assume that about 10% of cases are serious enough to require hospitalization. (Keep in mind that for many patients, hospitalization lasts for *weeks* — in other words, turnover will be *very* slow as beds fill with COVID19 patients).

By this estimate, by about May 8th, all open hospital beds in the US will be filled. (This says nothing, of course, about whether these beds are suitable for isolation of patients with a highly infectious virus.)

If we’re wrong by a factor of two regarding the fraction of severe cases, that only changes the timeline of bed saturation by 6 days in either direction. If 20% of cases require hospitalization, we run out of beds by ~May 2nd.

If only 5% of cases require it, we can make it until ~May 14th. 2.5% gets us to May 20th. This, of course, assumes that there is no uptick in demand for beds from *other* (non-COVID19) causes, which seems like a dubious assumption.

As healthcare system becomes increasingly burdened, Rx shortages, etc, people w/ chronic conditions that are normally well-managed may find themselves slipping into severe states of medical distress requiring intensive care & hospitalization. But let’s ignore that for now.

Alright, so that’s beds. Now masks. Feds say we have a national stockpile of 12M N95 masks and 30M surgical masks (which are not ideal, but better than nothing).

There are about 18M healthcare workers in the US. Let’s assume only 6M HCW are working on any given day. (This is likely an underestimate as most people work most days of the week, but again, I’m playing conservative at every turn.)

As COVID19 cases saturate virtually every state and county, which seems likely to happen any day now, it will soon be irresponsible for all HCWs to not wear a mask. These HCWs would burn through N95 stockpile in 2 days if each HCW only got ONE mask per day.

One per day would be neither sanitary nor pragmatic, though this is indeed what we saw in Wuhan, with HCWs collapsing on their shift from dehydration because they were trying to avoid changing their PPE suits as they cannot be reused.

How quickly could we ramp up production of new masks? Not very fast at all. The vast majority are manufactured overseas, almost all in China. Even when manufactured here in US, the raw materials are predominantly from overseas...again, predominantly from China.

Keep in mind that all countries globally will be going through the exact same crises and shortages simultaneously. We can’t force trade in our favor.

Now consider how these 2 factors – bed and mask shortages – compound each other’s severity. Full hospitals + few masks + HCWs running around between beds without proper PPE = very bad mix.

HCWs are already getting infected even w/ access to full PPE. In the face of PPE limitations this severe, it’s only a matter of time. HCWs will start dropping from the workforce for weeks at a time, leading to a shortage of HCWs that then further compounds both issues above.

We could go on and on about thousands of factors – # of ventilators, or even simple things like saline drip bags. You see where this is going.

Importantly, I cannot stress this enough: even if I’m wrong – even VERY wrong – about core assumptions like % of severe cases or current case #, it only changes the timeline by days or weeks. This is how exponential growth in an immunologically naïve population works.

Undeserved panic does no one any good. But neither does ill-informed complacency. It’s wrong to assuage the public by saying “only 2% will die.” People aren’t adequately grasping the national and global systemic burden wrought by this swift-moving of a disease.

I’m an engineer. This is what my mind does all day: I run back-of-the-envelope calculations to try to estimate order-of-magnitude impacts. I’ve been on high alarm about this disease since ~Jan 19 after reading clinical indicators in the first papers emerging from Wuhan.

Nothing in the last 6 weeks has dampened my alarm in the slightest. To the contrary, we’re seeing abject refusal of many countries to adequately respond or prepare. Of course some of these estimates will be wrong, even substantially wrong.

But I have no reason to think they’ll be orders-of-magnitude wrong. Even if your personal risk of death is very, very low, don’t mock decisions like canceling events or closing workplaces as undue “panic”.

These measures are the bare minimum we should be doing to try to shift the peak – to slow the rise in cases so that healthcare systems are less overwhelmed. Each day that we can delay an extra case is a big win for the HC system.

And yes, you really should prepare to buckle down for a bit. All services and supply chains will be impacted. Why risk the stress of being ill-prepared? 28/n Worst case, I’m massively wrong and you now have a huge bag of rice and black beans to burn through over the next few months and enough Robitussin to trip out.

One more thought: you’ve probably seen multiple respected epidemiologists have estimated that 20-70% of world will be infected within the next year. If you use 6-day doubling rate I mentioned above, we land at ~2-6 billion infected by sometime in July of this year.

Obviously I think the doubling time will start to slow once a sizeable fraction of the population has been infected, simply because of herd immunity and a smaller susceptible population.

But take the scenarios above (full beds, no PPE, etc, at just 1% of the US population infected) and stretch them out over just a couple extra months. 32/n That timeline roughly fits with consensus end-game numbers from these highly esteemed epidemiologists. Again, we’re talking about discrepancies of mere days or weeks one direction or another, but not disagreements in the overall magnitude of the challenge.

This is not some hypothetical, fear-mongering, worst-case scenario. This is reality, as far as anyone can tell with the current available data.

That’s all for now. Standard disclaimers apply: I’m a PhD biologist but *not* an epidemiologist. Thoughts my own. Yadda yadda. Stay safe out there. /end

1 posted on 03/06/2020 10:19:16 PM PST by ProtectOurFreedom
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To: ProtectOurFreedom

74 posted on 03/07/2020 4:11:53 AM PST by Travis McGee (EnemiesForeignAndDomestic.com)
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To: ProtectOurFreedom

“We’re looking at about 1M US cases by the end of April, 2M by ~May 5, 4M by ~May 11, and so on.”

Her numbers are way off base. China has been dealing with the Virus since January. It has only 80,000 or so cases and the world count is 100,000 - after over two months global exposure.


79 posted on 03/07/2020 5:23:19 AM PST by Wuli
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To: ProtectOurFreedom

Assuming none of the drugs now under investigation do nothing.

THat’s what is wrong w/ his analysis. I’ve read several reports about different candidates under investigation.


80 posted on 03/07/2020 5:27:16 AM PST by sauropod (David Horowitz: “Inside every progressive is a totalitarian screaming to get out.”)
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To: ProtectOurFreedom

thank you for posting this


81 posted on 03/07/2020 5:34:49 AM PST by wafflehouse (RE-ELECT NO ONE !)
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To: ProtectOurFreedom

It’s just a hoax flu that only affects old people and is a conspiracy against Trump.

/demented FReepers.


86 posted on 03/07/2020 5:43:54 AM PST by Rebelbase
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To: ProtectOurFreedom

Relax..... it ain’t gonna happen. Speculative extrapolation is fallacious

A disease has morphed into a political crisis that has kill Trump as it’s primary basis


87 posted on 03/07/2020 5:46:47 AM PST by bert ( (KE. NP. N.C. +12) Progressives are existential American enemies)
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To: ProtectOurFreedom

Some Freepers posting here apparently don’t understand exponential growth either.


96 posted on 03/07/2020 6:18:01 AM PST by 9YearLurker
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To: ProtectOurFreedom

I turn 65 next month. Not sure if I want to visit any medical facility.

I need cataract surgery — may decide to wait for now.


101 posted on 03/07/2020 7:35:57 AM PST by George from New England (escaped CT in 2006, now living north of Tampa)
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To: ProtectOurFreedom

Gee. Why stop your analysis at the collapse of the hospital system? If that happens, there will be a next day. What happens then?

I think I saw this movie.


102 posted on 03/07/2020 7:44:09 AM PST by VanShuyten ("...that all the donkeys were dead. I know nothing as to the fate of the less valuable animals.")
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To: ProtectOurFreedom
Let’s conservatively assume that there are 2,000 current cases in the US today, March 6th

Probably off by a factor of ten or more. Lots of asymptomatic transmission going on on the West Coast.

But the system won't have to wait for HCWs to get sick to collapse, because enough of them will be in quarantine by the end of April to collapse it.

120 posted on 03/10/2020 1:47:21 AM PDT by Jim Noble (There is nothing racist in stating plainly what most people already know)
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