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Tokyo scientists find hair loss gene in mice
News.com.au ^ | May 26, 2009

Posted on 05/26/2009 11:09:46 AM PDT by Schnucki

* Study finds hair loss gene in mice * Gene shared by both mice and humans * Could lead to cure of baldness in humans

EXPERIMENTS on mice have revealed a gene that is linked to early hair loss, a Japanese researcher said today, sparking hopes for a treatment to prevent thinning and baldness in humans.

The research team found that the absence of a gene known as Sox21 -- which it said is shared by humans and mice -- can lead to early hair loss.

The scientists biologically engineered mice by blocking the gene and found that the rodents started losing hair on their heads about 15 days after birth and became completely naked a week later.

"Normally, new hair appears right after old hair falls out," said Yumiko Saga, a mammalian development professor at the National Institute of Genetics.

"But the hair of these mice fell out very early, making their bald periods longer," she said, adding that although the mice started to grow new fur, the replacement hair also kept falling out quickly.

The Sox21 gene has in the past been shown to be linked to the formation of nerve cells, but the Japanese study was the first to indicate its function in ensuring hair retention, she said by telephone.

"It is entirely possible that the gene is also a cause of thinning hair among humans", Saga said.

The study, jointly conducted with Hideyuki Okano, professor at the School of Medicine at Tokyo's Keio University, found that the lack of the gene leads to the improper formation of cuticles, the outer layer of hair.

"Cuticles usually have a scaled structure, locking hair in the scalp," said Saga. Blocking the gene in the mice meant that their cuticles lacked this structure, making the hair fall out more quickly,

(Excerpt) Read more at news.com.au ...


TOPICS: Culture/Society; Extended News
KEYWORDS: animalresearch; baldness; genetics; hair
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1 posted on 05/26/2009 11:09:46 AM PDT by Schnucki
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To: Schnucki

If I didn’t do such a cunning and undetectable comb over I might find this interesting.


2 posted on 05/26/2009 11:10:53 AM PDT by DManA
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To: Schnucki
The good news is, this may lead to a cure for baldness. The bad news is, that it may lead to a baldness pill...which could possibly haunt us with the same frequency as the Viagra/Cialis/Levitra commercials.
3 posted on 05/26/2009 11:12:53 AM PDT by americanophile
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To: Schnucki

Hurry please.


4 posted on 05/26/2009 11:12:53 AM PDT by AngryJawa (Obama's Success is America's Failure)
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To: DManA

Forget the tests-I’m buying!


5 posted on 05/26/2009 11:13:06 AM PDT by Dr. Ursus
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To: Schnucki

Great news for bald mice.


6 posted on 05/26/2009 11:13:20 AM PDT by dfwgator (1996 2006 2008 - Good Things Come in Threes)
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To: Schnucki

Women married to mice will be thrilled.


7 posted on 05/26/2009 11:16:30 AM PDT by VeniVidiVici (Putin warned Obama not to pursue Marxism. Obama has ignored him.)
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To: DManA

I'm going bald and I'm behind the 8 Ball.
8 posted on 05/26/2009 11:20:25 AM PDT by dblshot
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To: Schnucki

1. New drug approval takes 11 years, typically

2. Would be the first approved gene-based therapy —longer than 11 years, then, most likely

3. Companies would try to structure the treatment so that doses would be required forever

Still very interesting, of course


9 posted on 05/26/2009 11:21:51 AM PDT by gaijin
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To: Schnucki
a mammalian development professor

For a moment I thought this said "mammarian development professor"...

I look at it as: "Less hair to comb, more face to wash."
I don't recall who said that first, but he was right.

10 posted on 05/26/2009 11:25:53 AM PDT by theDentist (qwerty ergo typo : i type, therefore i misspelll)
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To: gaijin

Eleven years? I’ll have cornered the Finasteride market by then.


11 posted on 05/26/2009 11:28:57 AM PDT by skeeter
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To: Schnucki

Three bald mice, three bald mice, see how they ....


12 posted on 05/26/2009 11:29:09 AM PDT by G Larry (ObamaCare = "DYING IN LINE!")
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To: Schnucki
A little to late for me you smucks!....
13 posted on 05/26/2009 11:34:00 AM PDT by AngelesCrestHighway
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To: AngryJawa

yes....mine is thinning by the day....


14 posted on 05/26/2009 11:34:07 AM PDT by God luvs America (When the silent majority speaks the earth trembles!)
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To: AngryJawa
of course with my luck this is what will happen a week after taking the cure....


15 posted on 05/26/2009 11:36:47 AM PDT by God luvs America (When the silent majority speaks the earth trembles!)
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To: God luvs America

What, you’ll turn into young Bill Gates?


16 posted on 05/26/2009 11:37:59 AM PDT by Revolting cat! (Let us prey!)
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To: God luvs America

What did you do?....stick your finger in a light socket?


17 posted on 05/26/2009 11:38:43 AM PDT by AngelesCrestHighway
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To: Schnucki

Grass doesn’t grow on a busy street.


18 posted on 05/26/2009 11:51:53 AM PDT by dainbramaged (If you want a friend, get a dog.)
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To: Schnucki
There comes a point in a mans life when you stop praying for a cure for baldness, and start praying for something that would get rid of the hair starting to grow where no hair has any purpose. I'm there.
19 posted on 05/26/2009 11:52:31 AM PDT by NavyCanDo
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To: Schnucki

Have we cured cancer yet?


20 posted on 05/26/2009 12:05:44 PM PDT by GOPGuide
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