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To: Fichori
Since thalidomide has a stereogenic carbon atom, it exists as two enantiomers. Tests with mice in 1961 suggested that only one enantiomer was teratogenic while the other possessed the therapeutic activity. Unfortunately, subsequent test with rabbits showed that both enantiomers had both activities.

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125 posted on 01/12/2009 11:41:33 AM PST by js1138
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To: js1138

I imagine there are a number of enantiomers that regardless of chirality are harmful to rabbits.

I also notice that the excerpt you posted referenced mice and rabbits being effected differently by the same thing.

The excerpt you posted did not address the affects that thalidomide had on humans. (Which is what the thread article referenced)


135 posted on 01/12/2009 12:00:44 PM PST by Fichori (I believe in a Woman's right to choose, even if she hasn't been born yet.)
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