West Coast for sure for fallout phobia post effect......large population , sea port as you state and where prevailing winds will do most damage to secondary large population centers.
I’d say San Diego with fallout pattern to Las Vegas NV and all points possible east of there if I was to SWAG the issue from here in the cheap seats !.........:o)
Nuclear targets based on known defense, value of target, population, and military sites
Effects of a ONE megaton nuclear detonation
If this does happen Mecca should become a pile of glass. And for kicks just blow up the Dome of the Rockl
I’d guess Seattle or Long Beach / LA, in a shipping container, set to go off upon reaching port. Just put a GPS detonator on it, to go off upon crossing the X longitude (in port).