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Three men have been arrested in connection with the suicide bombings in London on 7 July 2005.
Two men, aged 23 and 30, were arrested shortly before 1300 GMT at Manchester Airport when they were due to catch a flight to Pakistan.
A third man, aged 26, was arrested at a house in Leeds shortly after 1600 GMT.
The men were arrested on suspicion of the commission, preparation, or instigation of acts of terrorism under the Terrorism Act 2000.
A total of 52 people were killed on 7 July when Mohammed Sidique Khan, Shehzad Tanweer and Germaine Lindsay detonated bombs on three Tube trains and Hasib Hussain attacked a bus.
Searches
The arrests are the first major arrests since the attacks.
The men are being taken to a central London police station where they will be kept in custody and will be interviewed by officers from the Metropolitan Police's Counter Terrorism Command.
Searches are being carried out at five houses in the Beeston area of Leeds, West Yorkshire Police said.
A flat and a separate business premises are also being searched in east London.
Scotland Yard said the arrests were part of a pre-planned, intelligence-led operation and also involved the West Yorkshire Police Counter Terrorism Unit.
'Painstaking investigation'
Armed officers were not used.
Lord Carlile QC, the independent reviewer of terrorism legislation, said: "Anybody who imagined that this had simply been treated as four lone wolves, or a pack of wolves on 7 July 2005 was very wrong."
He said a "rigorous hunt" was going on for everyone connected with the attacks and nobody involved could "lie easy in their beds".
A Scotland Yard spokesman said: "Detectives have continued to pursue many lines of inquiry both here in the UK and overseas.
"This remains a painstaking investigation with a substantial amount of information being analysed and investigated.
"As we have said previously, we are determined to follow the evidence wherever it takes us to identify any other person who may have been involved, in any way, in the terrorist attacks.
"We need to know who else, apart from the bombers, knew what they were planning. Did anyone encourage them? Did anyone help them with money, or accommodation?"
http://news.bbc.co.uk/2/hi/uk_news/6481495.stm